See the value of ITC for SMDD
Differential scanning calorimetry (DSC) and isothermal titration calorimetry (ITC) have been extensively applied in our highly integrated small molecule drug discovery platform at Exelixis Inc. In this report, we will illustrate the utility of calorimetry in making better laboratory decisions. Examples will include improved protein construct selection for scale-up; direct measurement of the effects of mutations and post-translational modifications on protein stability; rapid optimization of solvent formulation; direct measurement of substrate and inhibitor binding affinity; determination of the mode of inhibitor binding; characterization of protein-protein interactions; and improved structural biology efficiency, when used in conjunction of other biophysical methods.
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