Polyol-induced increases in thermal stability of antibodies by DSC

See how DSC can be used to assess the effects of polyol excipients on antibodies. Differential scanning calorimetry was used to monitor polyol-induced increases in thermal stability across seven monoclonal antibodies. The increases in thermal stability were measured as a function of polyol concentration and orientation of hydroxyl groups. It was found that increases in thermal stability were linear with respect to alcohol concentration. Further, the increase in thermal stability was dependant on the transition temperature; antibodies with lower transition temperatures exhibited a greater increase due to the addition of polyols than antibodies with a higher transition temperature.

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