Thermal Stability Testing and Fingerprinting of biomolecules with Differential Scanning Calorimetry

Thermal Stability Tests are often used as a screening technique to predict the long term stability of protein formulations. Differential Scanning Calorimetry (DSC) has established itself in this application area as a gold standard, which can be universally applied to characterize thermal stability. In addition to the melting temperature, the method yields a thermodynamic fingerprint of the unfolding process, which can be used to derive insight into the mechanism of the unfolding process.

In his talk, Dr. Mark Wingfield, describes the DSC technique and shows with the help of applications from the field of therapeutic protein formulations, how it can be used to optimize formulation stability. The talk will be of interest to all scientists involved in the formulation of therapeutic proteins.


Dr. Mark Wingfield, Malvern Instruments, General Manager