Nanoparticules lipidiques

Optimize lipid nanoparticle formulation, manufacturing, and quality control with the right analytical tools

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What are lipid nanoparticles?

[LNP-diagram.jpg] LNP-diagram.jpg Lipid nanoparticles are small spherical vesicles formed of a mixture of ionizable cationic lipids, helper lipids (such as DSPC and cholesterol), and PEGylated lipids.

These tiny structures offer immense benefits as a drug delivery system, including:

  • Enabling delivery of a wide range of therapeutic payloads, from small molecules to oligonucleotides 
  • Superior safety (relative to viral vectors) 
  • Streamlined, cell-free manufacturing methods 
  • Potential for rapid manufacturing process scale-up 

Lipid nanoparticles have a range of medical applications, the most prominent being delivery of DNA and RNA payloads for prophylactic or therapeutic vaccines, in addition to other therapies. 

Overcoming lipid nanoparticle formulation development & manufacturing challenges

To better measure these attributes and support confident formulation decisions, developers and manufacturers need a suite of advanced, orthogonal biophysical characterization methods, including:

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Sample stability
Sample homogeneity
Sample concentration
ProductPEAQ DSCZetasizerNanoSightOMNISEC
Measurement
  • Higher order structure 
  • Thermal stability 
  • Thermal transitions
  • Particle size 
  • Particle concentration 
  • Polydispersity 
  • Zeta potential
  • Particle size 
  • Particle concentration 
  • Polydispersity 
  • Fluorescence detection
  • Polydispersity 
  • Therapeutic payload 
  • Weight fraction of payload
Technology

Lipid nanoparticle formulation development

Formulating lipid nanoparticle products to optimize their stability and therapeutic efficacy is no easy feat since formulation depends not only on the formulation components but also on the formulation process. 

Selecting the right formulation strategy demands deep and accurate insights into the attributes of your lipid nanoparticle samples, including:

  • Vector size
  • Concentration
  • Surface charge 
  • Composition
  • Thermal stability
Vector Analytics webinars
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Vector Analytics webinars

Explore our Vector Analytics webinar hub, where you’ll find insights, tips and advice from biophysical characterization and technology experts.


Malvern Panalytical offers the full range of tools and expertise to confidently characterize lipid nanoparticles for better formulation decision-making and faster program progression:

Zetasizer Ultra

Reliably measure vector size, concentration, and surface charge with the world’s most advanced light scattering system, with automated capabilities for higher throughput
Zetasizer Ultra

NanoSight Pro

Unlock the highest quality size and concentration measurements, quickly, with our easy-to-use NTA system
NanoSight Pro

Système MicroCal PEAQ-DSC

Accurately characterize thermal stability with a highly sensitive, easy-to-use DSC system
Système MicroCal PEAQ-DSC

OMNISEC

Confidently measure vector composition with the world’s most advanced multi-detector GPC/SEC system
OMNISEC

Lipid nanoparticle manufacturing and quality control

Manufacturing consistently high-quality lipid nanoparticle products poses numerous challenges. LNP developers must understand the impact of (and be able to optimize) manufacturing process parameters and be able to rapidly conduct batch-to-batch consistency and stability studies. 

What’s more, personalized medicines (which are the focus of many LNP therapies) can make QC testing and analysis much more demanding.

To succeed, LNP developers need deep, rapid, and accurate insights into the attributes of their LNP formulation, including:

  • Size
  • Concentration
  • Composition
  • Thermal stability

Malvern Panalytical provides the full range of analytical tools and expertise you need to confidently characterize your lipid nanoparticles to optimize manufacturing and drive quality:

Zetasizer Ultra

Reliably measure vector size, concentration, and surface charge with the world’s most advanced light scattering system, with automated capabilities for higher throughput
Zetasizer Ultra

NanoSight Pro

Unlock the highest quality size and concentration measurements, quickly, with our easy-to-use NTA system
NanoSight Pro

Système MicroCal PEAQ-DSC

Accurately characterize thermal stability with a highly sensitive, easy-to-use DSC system
Système MicroCal PEAQ-DSC

OMNISEC

Confidently measure vector composition with the world’s most advanced multi-detector GPC/SEC system
OMNISEC
Read our expert Q&A
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Read our expert Q&A

Discover what your peers are asking about lipid nanoparticle characterization

Lipid nanoparticle characterization solutions

With decades of experience in the field of pharmaceuticals, Malvern Panalytical has built a reputation for excellence. Our portfolio of innovative analytical technologies is designed to meet the complex needs of pharmaceutical and biopharmaceutical research, development, and manufacturing.

We are committed to continuous innovation and maintaining the highest standards of quality. By investing in research and development, Malvern Panalytical consistently introduces cutting-edge solutions that address the evolving challenges in pharmaceuticals, including dissolution testing.

To find out more about how our solutions can enhance your lipid nanoparticle formulation development and manufacturing processes, contact us today. Our experts are ready to provide you with detailed information, demonstrations, and tailored solutions to meet your needs.