The efficacy of RNA-based vaccines has been recently demonstrated, leading to the use of mRNA-based COVID-19 vaccines. mRNA vaccines can induce potent immune responses without the need of translocation into the cell nucleus. Furthermore, mRNA manufacturing can be optimized to be low-cost, fully synthetic and scalable. However, rapid, low-cost, global deployment of these vaccine, and nanomedicines in general, requires new manufacturing technologies. Consequently, vaccine developers need to understand of the impact of these manufacturing processes on nanoparticle characteristics and potency.
Join Professor Yvonne Perrie, from the University of Strathclyde's Institute of Pharmacy and Biomedical Sciences, as she shows you the scale-independent manufacture of these particles using microfluidics. She will also explore the role of formulation, using a range of nanoparticle systems, on critical attributes such as:
• particle size distribution
• zeta potential
About your speaker
Professor Yvonne Perrie is an internationally recognized expert in the field of liposomes and particulate drug delivery research. Her research focuses on the development of drug delivery systems for drugs and vaccines, providing practical solutions for current healthcare problems.
Overseeing a laboratory fully equipped for the manufacture and analysis of a wide range of nanoparticles, and to date has translated her research into six patents and approximately 130 peer-reviewed articles. Prof. Perrie's research and academic leadership have been recognized via a range of fellowships and awards, including, most recently, the Royal Pharmaceutical Society Harrison Memorial Medal (2019).
Professor Yvonne Perrie - Professor in Drug Delivery - University of Strathclyde, Glasgow, Institute of Pharmacy and Biomedical Sciences
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Who should attend?
Scientists and project leaders working on the design, process and formulation development of lipid nanoparticles and liposomes for drug and vaccine delivery.
What will you learn?
- How microfluidic process parameters impact critical attributes for nanoparticle systems.
- How size and poly dispersity is used to optimize, monitor and control mRNA-LNPs
- The impact of formulation on bio distribution and the immunogenicity response of mRNA-based vaccines
- Discover a range of tools help you accelerate the development of safe and effective vaccines