Particle size, shape and dissolution

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00:00:00 Particle size, Shape and Dissolution
00:02:09 Particle size, shape, and dissolution
00:03:10 Format
00:04:11 Abstract
00:05:25 Obligatory opening quotations
00:06:27 Introduction
00:07:48 M H Rubinstein “Particle Size Analysis as a Predictor of Dissolution Rate/Bioavailability” Anal. Proc. (London), 18, 512 - 514 (December 1981)
00:08:19 Heywood
00:09:14 Why measuring size is easier than relating to the final properties (Heywood)
00:10:38 Effect of size reduction for the same material MK-869
00:11:45 Fundamental theory
00:12:20 Noyes-Whitney
00:13:02 Noyes-Whitney (MIT)
00:14:01 Basic simple equation
00:15:12 Adapted from Umesh V Banakar “Pharmaceutical Dissolution Testing” Informa Healthcare Drugs and the Pharmaceutical Sciences Series Volume 49 (2010) page 7
00:16:30 “Modified” form
00:17:33 Noyes-Whitney
00:18:32 Effect of particle size on dissolution of Nevirapine tablets
00:19:39 Clearly the smaller the size, then the faster the dissolution
00:20:31 Prediction of solubility Basic Physical Chemistry – back to college
00:21:48 Prediction of solubility
00:23:20 Moore page 298
00:25:00 Harry Brittain: 3.7 “Solubility Methods for the Characterization of New Crystal Forms” page 323 - 346 Editors: Moji Christianah Adeyeye & Harry G Brittain “Preformulation in Solid Dosage Form Development” Informa Healthcare Drugs and the Pharmaceutical Sc
00:27:05 Variables to control
00:28:24 Other factors controlling dissolution
00:30:05 Instrumental factors
00:31:08 Dissolution example
00:31:39 USP Study (2007)
00:32:16 Dissolved gas – after Bill Hanson William A Hanson “Handbook of Dissolution Testing” Pharmaceutical Technology Publications (1982) page 79
00:32:54 Quality of vessel
00:33:25 Dissolution example
00:34:10 Solubility of Zidovudine at 25oC
00:34:34 Solubility of Artesunate
00:34:53 Decomposition of Artesunate in aqueous solution
00:35:41 So, what should we see with time?
00:36:23 Modification of the equation
00:37:29 Polydispersity
00:37:56 Single particle
00:38:25 Single Particle Example
00:39:51 Hypothesis
00:40:51 Relation of blood level concentration with size
00:41:45 Testing Methods
00:42:50 USP <711>
00:43:22 Basket and Paddle
00:44:16 Verification
00:44:45 USP <711> Intent to Revise
00:45:07 USP <711>
00:45:35 Harmonization
00:46:11 Verification
00:46:29 Type 3 dissolution apparatus Reciprocating Cylinder
00:46:56 Novel method using rheology
00:47:59 Be aware…
00:48:44 Early work on aspect ratio Carstensen
00:49:39 “Isometricity”
00:50:04 From Umesh V Banakar “Pharmaceutical Dissolution Testing” Informa Healthcare Drugs and the Pharmaceutical Sciences Series Volume 49 (2010) page 11
00:50:36 Effect of shape/polymorphs
00:51:41 Snyder, Doherty (2007)
00:52:28 Polymorphs
00:53:18 Snyder, Doherty (2007)
00:53:49 Purdue/Abbott collaboration
00:54:40 Purdue/Abbott collaboration
00:55:04 Poorly soluble materials
00:55:51 Elaine M Merisko-Liversidge, G G Liversidge “Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds” Toxicologic Pathology, 36:43 – 48, (2008)
00:56:37 Reference List
00:57:25 References (contd.)
00:57:52 References
00:58:09 Summary
00:58:58 Thank you!
00:59:27 Contact Information
Here we'll be discussing the important link between particle size and dissolution rate, with particular reference to the pharmaceutical industry. The importance of dissolution in relation to bioavialability assessment will be highlighted.