| 00:00:00 | Improving your granulation process with on-line sizing measurements |
| 00:00:54 | Inline particle size analysis for fluidized & high shear granulation processes |
| 00:01:04 | Agenda |
| 00:01:32 | Why off-line? |
| 00:02:20 | Why off-line? |
| 00:03:27 | Concerns with off-line technology |
| 00:05:01 | Concerns with off-line technology |
| 00:05:24 | Why Consider Online? |
| 00:06:15 | Why Consider Online? |
| 00:06:46 | Technical challenges - measuring in the process |
| 00:07:47 | PAT in everywhere |
| 00:08:32 | PAT in granulation processes |
| 00:10:27 | PAT in granulation processes |
| 00:13:06 | SFT – Spatial Filter Velocimetry technique |
| 00:13:25 | SFT – Spatial Filter Velocimetry technique |
| 00:14:43 | SFT – Spatial Filter Velocimetry technique |
| 00:16:04 | Fluidised bed granulation – Glatt GPCG 15 |
| 00:17:05 | Fluidised bed granulation – Glatt GPCG 15 |
| 00:18:14 | Batch fluidised bed granulator - 300kg - Pharma |
| 00:19:09 | Glatt ProCell GF25 |
| 00:20:16 | Glatt ProCell GF25 |
| 00:20:46 | Pilot Processor System P/VAC 10 - 60 |
| 00:21:22 | Pilot Processor System P/VAC 10 - 60 |
| 00:21:48 | Similar test |
| 00:22:11 | Similar test |
| 00:22:59 | Laser diffraction |
| 00:23:20 | Insitec sampling and measurement system |
| 00:23:44 | Fluidized bed granulation |
| 00:23:56 | Impact of compaction force |
| 00:25:10 | Summary |
| 00:26:03 | Thank you very much! |
| 00:26:09 | Contact Information |
Particle size is a critical control parameter in many different industries including pharmaceuticals, chemicals, coatings, and mining. Particle size distribution plays a major role in determining the performance of the end product, so producing the correct particle size distribution is vital in those processes. As a result, PAT (Process Analytical Technologies) are essential both for real-time Quality Control and for process understanding and development. This presentation introduces the Spatial Filter Velocimetry technology (SFT) for inline particle size measurement in granulation and fluidized bed processes.