Optimizing amorphous solid dispersions with diffraction techniques - A formulation option for poorly soluble APIs

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Amorphous solid dispersions (ASDs) present a formulation option for poorly soluble drugs intended for oral administration. They work by molecularly dispersing the drug substance in a water-soluble polymer, thereby disrupting the intermolecular bonds that would otherwise form a crystal. Once the polymer dissolves, the drug molecule is also in solution and therefore available for absorption. However, not all drug substances are compatible with the polymer, the released molecule is in a transient supersaturated state, and the long-term stability of ASDs is not guaranteed. 

In this webinar, we will discuss how particle size and solid-state analysis are useful metrics for optimizing the preparation and understanding the performance of ASDs.

This will include: 

  • An overview of the topic
  • Details on the relevant material characterization technologies
  • Examples from the literature


  • Dr. Robert Taylor - Segment Marketing Manager - Subject Matter Expert

Pour en savoir plus

Who should attend?

  • Anyone working with APIs which have poor solubility
  • Anyone developing amorphous solid dispersions
  • Anyone interested in material characterization to support ASD development
  • Anyone engaged in the development of oral solid dosage formulations
  • Anyone interested in particle size or solid-state analysis techniques

What will you learn?

  • Learn about some of the challenges for amorphous solid dispersions
  • Learn how particle size and solid-state analysis can help you overcome these challenges
  • Review how these techniques work
  • Discover how to employ these techniques in strategies for ASDs
  • Discover analytical resources to support your needs