Gene therapy is an area of rapid growth within the biopharmaceutical sector which uses genes to treat or prevent a disorder. The vectors which are used in gene therapy can be viral, non-viral and engineered vectors. In this work, we are focusing on a single viral vector used in gene therapy, recombinant adeno associated viruses (rAAV). 

In this application note rapid, accurate, and robust quantitative measurements of viral titer and full capsid content for AAV samples will be described. This study will demonstrate the capabilities of OMNISEC and ZS Ultra for analyses of rAAV5 samples at different levels of genome loading and sample heterogeneity.

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