Inhaler and nebuliser characterization

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00:00:00 Inhaler and nebulizer characterization
00:01:17 Inhaler and nebuliser characterisation
00:01:47 Inhaled drug deposition: important parameters
00:03:37 Spray characterisation: cascade impaction
00:05:19 Cascade impaction: advantages and disadvantages
00:07:25 Spray characterisation: why use laser diffraction?
00:09:50 How do laser diffraction systems measure particle size distributions?
00:11:06 How do laser diffraction systems measure particle size distributions?
00:12:19 Spraytec light scattering data
00:13:35 Comparing laser diffraction within cascade impaction
00:17:09 Laser diffraction: accessories for pharmaceutical spray measurements
00:18:29 What information does laser diffraction provide?
00:20:25 Dry Powder Inhalers: overview
00:21:16 A common view of dry powder dispersion…
00:22:06 The device and formulation must be considered together…
00:23:16 Hypothesis for dry powder delivery
00:23:57 Laser Diffraction study: experimental detail
00:25:11 Particle size flow rate dependence for the unprocessed lactose powder
00:26:04 Particle size flow rate dependence for the blended lactose / MgSt sample
00:26:43 Particle size flow rate dependence for the mechanofused lactose / MgSt sample
00:27:25 Concentration as a function of time for the blended lactose / MgSt sample
00:28:18 Concentration as a function of time for the mechanofused lactose / MgSt sample
00:29:17 Co-processing fine powders leads to changes in aerosolisation behaviour…
00:30:24 Co-processing fine powders leads to changes in aerosolisation behaviour…
00:30:46 Malvern Image Analysis Instrumentation
00:32:09 How does image analysis work?
00:33:25 Using shape to quantify agglomerates
00:35:34 Scattergram - Agglomerates
00:37:13 Scattergram – Primary Particles
00:37:58 Scattergram - Excipient Particles
00:38:56 Carrier free formulations
00:40:19 Effect of coating on circularity
00:42:01 Effect of coating on dispersion
00:43:30 Effect of coating on emitted dose
00:45:33 Nebulisers: overview
00:47:11 Gas-driven jet nebuliser performance
00:48:22 Breath-assisted nebuliser operation
00:50:04 Breath-assisted nebuliser operation: size histories for different breathing rates
00:50:45 Breath-assisted nebuliser operation: profiles for different formulation viscosities
00:51:46 Acknowledgements
00:52:04 Conclusions
00:53:06 Comparing laser diffraction within cascade impaction
00:56:33 Contact Information
Here we describe the use of the Spraytec in optimizing the performance of pharmaceutical inhaler and nebuliser systems.