Differential scanning calorimetry (DSC) is a technique that is broadly used in the biotherapeutic industry to measure protein stability. It can be used to measure both the intrinsic stability of a protein and the extrinsic stabilization by excipients and other non-active ingredients. The technique can be fully automated allowing for up to 50 runs a day. In this presentation a number of examples of how the technique is applied in pre/formulations, process development and manufacturing of protein drugs is outlined.