T cells can develop an exhausted phenotype as a result of prolonged antigen stimulation. This exhausted phenotype can occur in both CD4⁺ and CD8⁺ T cells and has been shown to develop within the tumor microenvironment as a potential mechanism by which tumour cells can escape immune surveillance. Here we describe an in vitro human exhausted T cell model that can be used as a valuable tool to assess the ability of candidate immuno-oncology therapeutics to rescue an exhausted T cell phenotype, restore T cell function and permit tumor cell clearance. In addition to efficacy of anti-PD-1 treatment, we demonstrate the ability of an inhibitor of a novel target to restore effector T cell function. Please login or register for free to read more.
- Contract Research - Biology