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Application Note

27 June 2022 | English

Measuring the Molecular Weight and dimer % of a protein with Zetasizer Advance

Understanding the behavior of proteins under different conditions is fundamental in several application areas such as biopharmaceuticals and health research. One parameter that can be used to understand protein behavior is absolute molecular weight (Mw). Knowing the molecular weight of a protein in monomeric form enables you to track that protein’s behavior such as dimerization and monitor the stability of your protein sample under different conditions by detecting aggregation. This application note will demonstrate how using the new concentration trends feature, a user can accurately calculate the absolute Mw of molecules in solution, and how this Mw value can be useful for detecting behavioral changes such as self-assembly in a protein sample. Please login or register for free to read more.

Products:
Zetasizer Advance Range
Technology:
Dynamic Light Scattering
Industry:
Biologics
Measuring the Molecular Weight and dimer % of a protein with Zetasizer Advance
Poster

21 June 2022 | English

Demonstrating restoration of T cell function in exhausted T cells with IKZF3 small molecule inhibitor, Lenalidomide

T cells can develop an exhausted phenotype as a result of prolonged antigen stimulation. This exhausted phenotype can occur in both CD4⁺ and CD8⁺ T cells and has been shown to develop within the tumor microenvironment as a potential mechanism by which tumour cells can escape immune surveillance. Here we describe an in vitro human exhausted T cell model that can be used as a valuable tool to assess the ability of candidate immuno-oncology therapeutics to rescue an exhausted T cell phenotype, restore T cell function and permit tumor cell clearance. In addition to efficacy of anti-PD-1 treatment, we demonstrate the ability of an inhibitor of a novel target to restore effector T cell function. Please login or register for free to read more.

Products:
Contract Research - Biology
Industry:
Pharmaceutical
Demonstrating restoration of T cell function in exhausted T cells with IKZF3 small molecule inhibitor, Lenalidomide