Table of contents
3. Nebulizers – Achieving bioequivalence using laser diffraction and automated imaging
00:08
5. A Moment of Truth…
00:26
6. Laser diffraction measures droplet and particle size distributions using light scattering
00:45
7. Dependence of light scattering on particle size
00:42
8. Spray characterisation: why use laser diffraction?
00:05
9. Laser diffraction is applied to understanding the delivery of the drug product
01:05
10. Morphological imaging techniques are now widely applied in OINDP bioequivalence testing
00:38
11. Morphological imaging enables particle classification on the basis of the size and shape of particles
00:30
12. Convexity-State of Dispersion
00:36
13. The data obtained by imaging can be used to understand the state of dispersion of samples
00:05
14. The workflow can be extended to enable component specific measurements if required
00:55
16. Pulmicort Respules: drug product specific guidance
00:35
17. Pulmicort Respules: in vitro bioequivalence tests
00:21
18. Laser diffraction measurements can be made either using an open measurement zone or a flow cell
00:14
19. For open bench measurements, the position of the nebuliser and extraction unit must be considered
00:44
20. Influence of receiver distance on the measured nebulizer droplet size
01:03
21. Influence of nebulizer distance on the measured droplet size
00:43
22. Influence of extraction distance on the measured nebulizer droplet size
00:32
23. Influence of extraction flow rate on the measured nebulizer droplet size
00:05
24. Droplet size measurement RSD recorded for each method parameter
00:48
25. Open bench method recommendations
00:41
26. Laser diffraction: flow cell measurements
00:57
27. Comparison between laser diffraction and cascade impaction for nebuliser measurements
00:43
28. Flow cell measurements: affect of breathing rate on breath-assisted nebuliser operation
00:57
29. Drug and agglomerate particle size analysis using morphological imaging
00:57
30. Innovator formulation: CE Diameter distributions
00:25
31. Generic formulation: CE Diameter distributions
00:34
32. Innovator & Generic: CE Diameter
00:51
34. Thank you for your attentionAny questions?
03:22
35. Contact Information
00:19