Diffraction in drug development

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Controlling solid form is a key concern from the moment lead compounds are crystallized, all the way through to commercial manufacture. And as a lead becomes a candidate molecule, it’s important to understand how its particles are distributed and how they behave. The particle size distribution and purity of an API are often controlling factors in how it moves, packs and dissolves – and this, in turn, can impact the final drug product’s bioavailability, efficacy, and even its safety.

Consequently, solid form and particle size distribution are critical material attributes that must be measured and controlled. X-ray diffraction and laser diffraction are used for this purpose. They provide complementary information on particle size and crystallo-chemical composition. 

In this webinar, we will discuss: 

  • the fundamental differences between X-ray diffraction and laser diffraction
  • the insights provided by these two techniques
  • guidance for method development for both XRD and LD particle sizing

We’ll also show you how Malvern Panalytical and Concept Life Sciences can support these activities in your drug development workflows.


  • Dr. Martin Schreyer - Application Specialist XRD - Malvern Panalytical 
  • Dr. Robert Taylor - Segment Marketing Manager Pharmaceuticals - Malvern Panalytical

More information

Who should attend? 

  • Anyone using or developing methods for XRD or laser diffraction
  • Anyone involved in API stability studies
  • Anyone engaged in pharmaceutical chemical development or the support of scale-up activities
  • Anyone engaged in polymorph screening as part of lead optimization activities
  • Anyone who is developing pharmaceutical formulations

What will you learn?

  • Learn how to apply X-ray diffraction and laser diffraction techniques 
  • Find out about method development for both technologies
  • Understand how Malvern Panalytical can support method development and transfer for both X-ray diffraction and laser diffraction particle sizing 
  • Discover how Concept Life Sciences can support your drug development projects