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Technical Note

17 May 2021 | English

Using your MicroCal Automated PEAQ-DSC in a BSL-2 laboratory

Are you studying viruses, toxins, infectious agents, pathogens or infectious organisms which pose a moderate hazard to humans or the environment? Are you using differential scanning calorimetry (DSC) for characterization? If you answered YES, you likely have your instrument in a Biosafety Level 2 (BSL-2) lab. This means your DSC needs to be safely decontaminated after use.

Products:
MicroCal PEAQ-DSC
Technology:
Differential Scanning Calorimetry (DSC)
Measurement type:
Particle size
Using your MicroCal Automated PEAQ-DSC in a BSL-2 laboratory
Technical Note

13 April 2021 | English

Zetasizer terminology

The Zetasizer ZS Xplorer software is a powerful tool for size and zeta potential measurements. There are several ways for you to customize your workspace and tables in the software with an abundance of parameters to choose from. Understanding the meaning behind all the terms enables you to appreciate both the hardware and software’s versatility. Furthermore, having a glossary of these terms provides valuable insight.

Products:
Zetasizer Advance Range
Technology:
X-ray Fluorescence (XRF)
Measurement type:
Particle size
Zetasizer terminology
Technical Note

09 March 2021 | English

Introducing Extended Size Range analysis for Zetasizer Advance

Whilst dynamic light scattering (DLS) is a ubiquitous tool for the characterization of nanomaterials, there may be cases where we want to also know about larger material that might also be present within the sample. Here we will introduce a new analysis model to help characterize particles at sizes not typically measurable via DLS with some examples of the benefits and limitations of this new feature.

Products:
Zetasizer Advance Range
Technology:
Dynamic Light Scattering
Measurement type:
Particle concentration
Introducing Extended Size Range analysis for Zetasizer Advance
Technical Note

24 November 2020 | English

Zetasizer Advance Series: Zeta Potential Measurements Data Interpretation

IntroductionThis technical note discusses interpretation of data and results obtained from zeta potential measurements in the ZS Xplorer software for the Zetasizer Advance series of instruments and highlights various parameters and charts that can be used to assess data and result quality. Recommended ParametersTable 1 shows a list of recommended parameters that are available in ZS Xplorer software which can be used to aid interpretation of the data and results obtained. Table 1: Recommended parameters for aiding data and result interpretation.Parameter NameDescription Zeta potentialThe mean zeta potential value in millivolts (mV) Zeta deviationThe standard deviation of the zeta potential distribution in millivolts (mV) ConductivityThe conductivity of the sample determined from the measurement in milli Siemens per centimeter (mS/cm) (Zeta Data) Mean count rateThe mean count from the measurement in kilo counts per second (kcps) at the attenuator selected for the measurement AttenuatorThe attenuator position used during the measurement (Zeta Data) Derived Mean Count RateThe normalized count rate (in kcps) obtained from the mean count rate and the attenuator selected for the measurement Reference beam count rateThe count rate of the reference beam (in kcps). This is set during instrument manufacture to be 2,600 ± 200 kcps Quality factorA signal to noise-based parameter derived from a phase analysis during the Fast Field Reversal (FFR) stage of the measurement SFR spectral quality factorA signal to noise-based parameter that is derived from the frequency analysis during the Slow Field Reversal (SFR)stage of the measurement Number of zeta runsThe number of sub runs used in the measurement Please login or register for free to read more.

Products:
Zetasizer Ultra
Technology:
Dynamic Light Scattering
Measurement type:
Zeta potential
Zetasizer Advance Series: Zeta Potential Measurements Data Interpretation
Technical Note

16 November 2020 | English

Size analysis method transfer – from Zetasizer Nano to Zetasizer Advance series

The Zetasizer Advance range is the new family of versatile light scattering instruments for measuring the particle size, zeta potential and molecular weight of dispersed nanomaterials via Dynamic, Electrophoretic and Static Light Scattering (DLS, ELS and SLS, respectively). This new range of instruments has been developed with the market-leading Zetasizer Nano range as its foundation. While there are many similarities between the Zetasizer Nano and Zetasizer Advance systems, this document aims to help you understand the differences and ensure that you are confident in transferring methods between instruments in the two ranges. The following topics will be covered: Hardware differencesCell compatibilitySample analysis Setting up methodsInterpreting resultsConsiderations for sample preparation procedures Please login or register for free to read more

Products:
Zetasizer Nano range
Technology:
Static Light Scattering
Measurement type:
Molecular weight
Size analysis method transfer – from Zetasizer Nano to Zetasizer Advance series
Technical Note

05 August 2020 | English

The Archimedes “Sneeze”: what is it and what does it really mean?

Operators of the Archimedes Particle Metrology System are frequent users of the fluidics feature known as the “Sneeze”. Most commonly it is activated as part of maintaining a clog-free microfluidic system. What exactly is happening during a sneeze is not well understood. Furthermore, the graphical display occurring during a sneeze can be misleading. In this technical note, we explain the mechanics of the Sneeze. We present a variety of scenarios and their resulting graphical output to illustrate and explain what is happening within the sensor and microfluidic system.

Products:
Archimedes
Technology:
Resonant Mass Measurement (RMM)
Measurement type:
Moisture content
The Archimedes “Sneeze”: what is it and what does it really mean?
Technical Note

18 July 2020 | English

Antibody drug conjugate services

Antibody-drug conjugates (ADCs) are attracting a significant amount of attention as they have the potential to revolutionize cancer treatment. Chemical ligation of cytotoxic agents to monoclonal antibodies allows the selective delivery of cytotoxins to tumor cells thereby potentially mitigating some of the damaging side-effects of cancer chemotherapy. There are currently a number of FDA-approved ADCs and numerous others at varying stages of development. Concept Life Sciences has expertise in all aspects of ADC synthesis and characterization to help expedite your ADC projects from discovery to the clinic.

Products:
Contract Research - Chemistry
Industry:
Pharmaceutical
Antibody drug conjugate services
Technical Note

01 July 2020 | English

Targeted protein degradation services

Concept Life Sciences offer a range of services important to any PROTAC® development programme. Our Medicinal, Synthetic and Computational Chemists, ADME Scientists and Biologists work closely together, allowing a flow of data and ideas between departments to help you accelerate your design-make-test cycle time.

Products:
Contract Research - Biology
Industry:
Pharmaceutical
Targeted protein degradation services
Technical Note

01 July 2020 | English

Nucleosides and nucleotides in drug discovery

Nucleosides and Nucleotides receive extensive synthetic attention due to their numerous uses in therapeutic and biotechnology applications. Examples include Sofosbuvir1, an important antiviral medication for the treatment of the hepatitis C virus (HCV) which works as a selective inhibitor of HCV NS5B polymerase with a high barrier to viral resistance, and more recently Remdesivir2 for its potential use in the treatment of Covid-19. Concept Life Sciences has unrivaled expertise in the synthesis of nucleosides and nucleosides from route development to synthesis of mg to kg scale.

Products:
Contract Research - Chemistry
Industry:
Pharmaceutical
Nucleosides and nucleotides in drug discovery
Technical Note

01 July 2020 | English

Fragment-based drug design

Over the last twenty years fragment-based drug design (FBDD) has emerged as one of the most prominent strategies used to identify innovative drug discovery Hits. FBDD presumes drug molecules are made of a combination of small fragments, each contributing to the a nity of the drug for its biological target. Unlike HTS, which aims to identify moderate to high a nity Hits the size of a typical drug molecule, fragment screening scouts for small molecule Hits with weaker but leaner a nity to their biological target. The FDBB strategy had led to many drug discovery successes including 4 approved drugs and another 40 under clinical investigation. At Concept Life Sciences, our FBDD service is designed to enhance success rate and speed of delivery.

Products:
Contract Research - Chemistry
Industry:
Pharmaceutical
Fragment-based drug design