Quality particles need quality dataParticle Works, a sister brand of Dolomite Microfluidics, develops and manufactures expertly engineered nanoparticle synthesis platforms for the pharmaceutical and biotech industries. Its innovative systems are used around the world to produce lipid nanoparticles (LNPs), important delivery vectors for mRNA-based medicines such as vaccines and gene therapy. Developing mRNA-based therapeutics is complex work, requiring highly skilled scientists, high-tech microfluidics platforms and sophisticated analytical equipment, and of course the mRNA itself. As Ben Knappett, Head of Science and Applications at Particle Works, points out: “You don't want to be constantly re-ordering highly expensive mRNA because your process is inefficient. We need ways of reproducibly and reliably generating the particles that encapsulate the mRNA.” LNP developers need reliable, high-quality data to optimize processes and product performance, and this only comes from analytics that provide a full and accurate understanding of their particles. In 2018, Particle Works added the Zetasizer Advance Ultra to its lab to deliver that data, robustly and quickly. The Zetasizer significantly reduced dependence on transmission electron microscopy (TEM), a reliable yet expensive, time-consuming and low-throughput process which became a limiting factor in production efficiency. Dr Knappett confirms that “The Zetasizer Advance has saved us time and money in terms of the experiments we carry out and in the data quality we get. It’s been a star in our lab for a long time now.” The Zetasizer Advance has saved us time and money in terms of the experiments we carry out and in the data quality we get. It's been a star in our lab for a long time now Ben Knappett — Head of Science and Applications, Particle Works
- Products:
- Zetasizer Advance Range, Zetasizer Ultra
- Technology:
- Multi-Angle Dynamic Light Scattering (MADLS), Dynamic Light Scattering
- Industry:
- Biologics, Pharmaceutical