Features and benefits

Central to the innovative, high performance Archimedes system is a MEMS…….add other parameters​

  • Low sample consumption​
  • Particle by particle analysis for size and concentration​
  • Resolution at atto gram scale​
  • Distinguish and simultaneously measure 2 material types​
  • User friendly software​
  • Multiple data views with 1-click​
  • Determine fluid density​

And is a truly orthogonal technology to light scattering methods for this size range.

Archimedes is an innovative, high-performance system which harnesses the technique of resonant mass measurement in order to detect and count particles in the size range 60nm - 5µm* and to measure particle mass and size. Archimedes is uniquely positioned to quantitatively measure protein aggregates in biotherapeutics in the size range 200nm - 5µm, highlighted as a particular concern for immunogenicity and product safety.

Central to Archimedes is a MEMS (Micro Electro-Mechanical Systems) technology sensor, allowing the highly sensitive, reliable and reproducible measurement of aggregates, one by one. Archimedes is also capable of providing information on sample concentration, polydispersity, density and volume, and distinguishing between negatively buoyant proteinaceous particles and positively buoyant contaminating silicone oil droplets.

Parameters measured:

  • Particle number.
  • Particle size.
  • Particle buoyant mass.
  • Particle dry mass.
  • Particle density.
  • Particle surface area.
  • Sample volume.
  • Sample concentration (particles/mL).
  • Sample density.

Key Benefits:

  • Ideally positioned for biopharmaceutical manufacturers and developers.
  • Unique and accurate particle counting capability in the size range 60nm - 5µm.
  • Exquisite sensitivity: measurement of particle mass to 2000ag.
  • Highly accurate particle size measurement from 60nm to 5µm.
  • Excellent size resolution, <20nm at 1µm diameter.
  • Low sample consumption: only 100µL.
  • Differentiation between negatively buoyant and positively buoyant particles.
  • Capable of measuring high concentration samples (to 109 particles/mL) and high viscosity samples (to 50cP).
  • Fast, NIST-traceable calibration.
  • Highly reproducible results.
  • Intuitive and flexible ParticleLab software.

*Sample and sensor dependent

Key applications

The Malvern Panalytical Archimedes can be used in many key applications, including:


With the ultimate goal of product quality, safety and efficacy, protein aggregate content of biotherapeutics should be measured and characterized under rigorous conditions, enabling maximum data integrity. Archimedes provides robust and repeatable measurements of protein aggregates 200nm – 5um in size.  When biotherapeutics are dosed pre-filled syringes, the silicon oil lubricant can contribute to the generation of aggregates and result in an immunogenic response. Archimedes is uniquely placed to differentiate contaminating silicon oil droplets from protein aggregates in a formulation.

Microbubbles/Ultra-sound Contrast Agents (UCA)​

Utility of UCA within medical imaging depends on their number concentration and their size distribution. However contaminating materials such as micelles can compromise their effectiveness. Archimedes’ RRM technology has the unique ability to distinguish and characterize positive buoyant bubbles from negative buoyant micelles and other contaminants that do not contribute to the ultrasound intensity.

Food & Dairy​

The size and composition of both milk fat particles as well as casein particles has been shown to affect the firmness of cheese, creaminess of ice cream and the flavour and mouth feel of chocolate. Archimedes’ RMM technology simultaneous measures the size of both fat-like and protein-like particles 200nm-5um in size. ​ This property allows the system to accurately quantify the mass-based size distribution of each component ensuring consistency in product quality.


From metallic nanoparticles to crystals, Archimedes is the tool for you if accuracy between 50nm -5µm is your focus. Archimedes has been utilized extensively to measure a variety of materials such as  metal oxides, silica, nanorods, metallic nanoparticles, calcite, inks, pigments, fragrance oils, graphite, CMP slurries, polymeric microspheres, iron oxide, silicon nitride…….and more


Archimedes is able to measure a wide range of parameters simply and quickly, following the principles of resonant mass measurement.

Measurement type 1: Particle Size

Measurement range:
60nm* - 5µm.
Better than +/- 1% on NIST traceable latex standards.
Precision / Repeatability:
Better than +/- 1% on NIST traceable latex standards.
Better than +/- 20nm at 1µm, polystyrene beads in H2O.

Measurement type 2: Particle Buoyant Mass

Lower Limit of Detection:
Better than +/- 3% on NIST traceable latex standards.
Precision / Repeatability:
Better than +/- 3% on NIST-traceable latex standards.

Measurement type 3: Particle Counting/Sample Concentration

Measurement range:
105 particles/ml – 108 particles/ml.
Better than +/- 10% on NIST traceable latex standards.
Precision / Repeatability:
Better than +/- 5% on NIST traceable latex standards.

Measurement principle: Resonant Mass Measurement.

Drawn sample volume:
Measured Sample Volume Range:
10nL - 10µL.
Sample Viscosity Range:
<1 cP - 50 cP
Accuracy in Fluid Density:
<0.002g/cc for densities in range 0.8g/cc – 1.2g/cc.
US 8087284 B2.
Light source:
685nm, 35mW laser.

Weight and dimensions

Dimensions (W, D, H):
610mm x 585mm x 305mm.
110V or 220V.

Operating environment

18°C – 25°C.
35% - 80% non-condensing.
Sample dependent


A small range of accessories and spares are available for Archimedes, adding flexibility and ease-of-use to the system.


Calibration standards


NIST monodisperse calibration standards for Micro and Nano sensors

Two types of NIST standards, one each for Hi-Q Micro and Nano sensors used in Archimedes.

More information Request a quote



The heart of Archimedes

MEMS (Micro Electro-Mechanical Systems) sensors provide the central functionality of Archimedes, enabling resonant mass measurement of particles.

More information Request a quote

Vials and seals

Two types of screw-top glass vial – 20mL and 40mL capacity - are available for use with Archimedes. By using the dedicated vial seals a snug fit to the instrument is created, enabling pressure to be maintained throughout Archimedes’ fluidics system.

  • 20mL screw-top glass vials.
  • Vial seals create a pressure-tight fitting.
  • Vials need only be finger-tight.
  • Additional seals available for snug fitting of fluidics lines into reference and waste bottles.
  • Inserts such as eppendorf tubes may be used for smaller sample volumes inside 20mL vial.
Visit store to buy now Request a quote

Reference fluid

Deuterated water is provided for use with Archimedes. Deuterated water provides a fluid density gradient inside Archimedes’ fluidics system, and should be pre-mixed with deionized water for optimal operation of the system measuring protein solutions

  • Deuterated water is used in small volumes to provide a density gradient in Archimedes and keep sample flow moving in the required direction.
  • Simple and intuitive use with Archimedes.
Visit store to buy now Request a quote


Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.

When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.

Help Desk


Software downloads

Malvern Panalytical's service options- choose the right plan for you:

Malvern Panalytical Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

Malvern Panalytical Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

Malvern Panalytical Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
Telephone / Email Support
Priority Response
Emergency Breakdown visits*
Parts Included
Technical & Software Support
IQ/OQ (Pharma)***

*including labour & travel costs***available at an additional cost