How can selecting appropriate storage conditions at the pre-clinical stage increase the efficiency of vaccine development? This webinar demonstrates how differential scanning calorimetry (DSC) can play a role in generating information that can be used to minimize waste and refrigeration costs throughout a vaccine’s life-cycle, from development to distribution and storage. You will also see how DSC data can inform the selection of storage-appropriate excipients during the post-clinical formulation process.
Understanding stability profiles
Ensuring efficient development of a protein therapeutic requires that a drug is formulated and stored in a manner that optimizes stability from the earliest stages of the process. Making assumptions on the appropriate conditions of storage can lead to costly issues later in the workflow. Instead, an orthogonal approach to understanding stability profiles during pre-clinical development of an antigen vaccine is required.
Case study: respiratory syncytial virus
In this webinar you’ll learn how size exclusion chromatography (SEC) was used to demonstrate an unexpected reduction in the potency of RSV (respiratory syncytial virus) antigen batches stored at different temperatures.
RSV virus infects ~ 60-70 million people each year and is responsible for 160,000 deaths per year globally.
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Matthew Scholfield from GSK & Verna Frasca of Malvern Panalytical
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Who should attend?
- Scientists and project leaders working on the discovery and development of protein-based vaccines and therapeutics.
What will you learn?
- The value of fully understanding the behavior of protein therapeutics under different storage conditions.
- The central role of DSC as part of an orthogonal approach to optimizing the formulation and storage conditions of vaccines.