記録された日時: January 17 2012

Duration: 01 hours 02 minutes 08 seconds

Here we'll be discussing the important link between particle size and dissolution rate, with particular reference to the pharmaceutical industry. The importance of dissolution in relation to bioavialability assessment will be highlighted.
Table of contents
1. Particle size, Shape and Dissolution
02:09
2. Particle size, shape, and dissolution
01:01
3. Format
01:01
4. Abstract
01:14
5. Obligatory opening quotations
01:02
6. Introduction
01:21
7. M H Rubinstein “Particle Size Analysis as a Predictor of Dissolution Rate/Bioavailability” Anal. Proc. (London), 18, 512 - 514 (December 1981)
00:31
8. Heywood
00:55
9. Why measuring size is easier than relating to the final properties (Heywood)
01:24
10. Effect of size reduction for the same material MK-869
01:07
11. Fundamental theory
00:35
12. Noyes-Whitney
00:42
13. Noyes-Whitney (MIT)
00:59
14. Basic simple equation
01:11
15. Adapted from Umesh V Banakar “Pharmaceutical Dissolution Testing” Informa Healthcare Drugs and the Pharmaceutical Sciences Series Volume 49 (2010) page 7
01:18
16. “Modified” form
01:03
17. Noyes-Whitney
00:59
18. Effect of particle size on dissolution of Nevirapine tablets
01:07
19. Clearly the smaller the size, then the faster the dissolution
00:52
20. Prediction of solubility Basic Physical Chemistry – back to college
01:17
21. Prediction of solubility
01:32
22. Moore page 298
01:40
23. Harry Brittain: 3.7 “Solubility Methods for the Characterization of New Crystal Forms” page 323 - 346 Editors: Moji Christianah Adeyeye & Harry G Brittain “Preformulation in Solid Dosage Form Development” Informa Healthcare Drugs and the Pharmaceutical Sc
02:05
24. Variables to control
01:19
25. Other factors controlling dissolution
01:41
26. Instrumental factors
01:03
27. Dissolution example
00:31
28. USP Study (2007)
00:37
29. Dissolved gas – after Bill Hanson William A Hanson “Handbook of Dissolution Testing” Pharmaceutical Technology Publications (1982) page 79
00:38
30. Quality of vessel
00:31
31. Dissolution example
00:45
32. Solubility of Zidovudine at 25oC
00:24
33. Solubility of Artesunate
00:19
34. Decomposition of Artesunate in aqueous solution
00:48
35. So, what should we see with time?
00:42
36. Modification of the equation
01:06
37. Polydispersity
00:27
38. Single particle
00:29
39. Single Particle Example
01:26
40. Hypothesis
01:00
41. Relation of blood level concentration with size
00:54
42. Testing Methods
01:05
43. USP <711>
00:32
44. Basket and Paddle
00:54
45. Verification
00:29
46. USP <711> Intent to Revise
00:22
47. USP <711>
00:28
48. Harmonization
00:36
49. Verification
00:18
50. Type 3 dissolution apparatus Reciprocating Cylinder
00:27
51. Novel method using rheology
01:03
52. Be aware…
00:45
53. Early work on aspect ratio Carstensen
00:55
54. “Isometricity”
00:25
55. From Umesh V Banakar “Pharmaceutical Dissolution Testing” Informa Healthcare Drugs and the Pharmaceutical Sciences Series Volume 49 (2010) page 11
00:32
56. Effect of shape/polymorphs
01:05
57. Snyder, Doherty (2007)
00:47
58. Polymorphs
00:50
59. Snyder, Doherty (2007)
00:31
60. Purdue/Abbott collaboration
00:51
61. Purdue/Abbott collaboration
00:24
62. Poorly soluble materials
00:47
63. Elaine M Merisko-Liversidge, G G Liversidge “Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds” Toxicologic Pathology, 36:43 – 48, (2008)
00:46
64. Reference List
00:48
65. References (contd.)
00:27
66. References
00:17
67. Summary
00:49
68. Thank you!
00:29
69. Contact Information
02:41