記録された日時: October 02 2018

Duration: 01 hours 05 minutes 03 seconds

Too often, the reason for carrying out a particle size distribution analysis is stated as “for QA”, or “I need the numbers”, or “because my boss says so”, or “for characterization”. Often, we can proceed deep into a project, having acquired huge amounts of data, with no real clarity about what is driving the measurement. 

This webinar explores the scientific reasons for performing a particle size distribution measurement, investigates bulk and dispersed particle sizes, and relates these to Critical Quality Attributes (CQAs) and Product Performance Indicators (PPIs).   

A product flowability issue is not solved by aggressive dispersion conditions that cannot be mimicked in the plant, as these flow properties are related to the bulk - not dispersed - particle size distribution.  Likewise, relating dissolution and bioavailability is best done on a dispersed sample, as most of the surface area will be available to the external continuous phase.  Understanding the reasons for making such a measurement leads to the setting of reasonable and achievable product specifications that are in line with the required product performance.

Table of contents
1. Welcome
00:08
2. Introduction
01:17
3. Why measure particle size (distribution)?
00:14
4. Abstract
00:05
5. Note in the title…
01:54
6. Why?
01:26
7. Heywood & Scarlett
01:08
8. BS and HH (and Stuart Bark on the LHS)
00:51
9. CQA’s and PFI’s
01:11
10. Critical to performance?
01:12
11. Why? Bulk Properties
01:26
12. Quality by Design
00:37
13. Why?
01:49
14. ‘Sample preparation’
02:38
15. Why?
01:24
16. Why Measure Particle Size?
00:50
17. The complicated picture
02:07
18. The military factor/connection
02:15
19. Battlefield smokes
01:37
20. Fuel droplet injection in jet engines
02:18
21. Insecticide
01:06
22. Sprays and aerosols
00:42
23. Insecticide
00:25
24. Insecticide
00:58
25. Lung entry – therapeutic!
01:15
26. LD50 for Pasteurella tularensis
00:53
27. The importance of aerodynamic diameter
00:54
28. So long thin particles can penetrate the lungs
00:52
29. Forthcoming FDA standard
00:19
30. The dynamic nature of a spray event
01:11
31. Which leads us onto emulsions
02:22
32. Jean-Louis Salager – another gentleman
01:01
33. Andriy Kyrylyuk* – Slide 26
01:01
34. Packing density
00:44
35. Road asphalt applications
00:30
36. Powders – why?
01:26
37. Why solids/powders?
00:30
38. Cement and (1-day) strength
01:03
39. Effect of particle size on tablet strength*
00:29
40. Why doesn’t my toilet fall apart when I sit on it?
01:49
41. Important properties - particle size distribution
00:50
42. Soils & sediments – erosion, permeability etc
00:54
43. Example - paints/coatings
00:20
44. Optical properties
01:12
45. Rubinstein (1981)
00:48
46. Example - pharmaceuticals
00:36
47. Noyes-Whitney
00:15
48. Basic simple equation
00:21
49. Noyes-Whitney (MIT)
00:24
50. Mining and minerals
00:41
51. Size effects at the nanoscale
00:47
52. Let’s not forget nano
00:36
53. Something you may not have thought of
00:30
54. Specification?
00:39
55. USP Workshop in 2010
00:36
56. The 4 Q’s
00:35
57. Summary and advice
00:44
58. Thank you for listening
07:52
59. Thank you for your attention
00:26