Your search for method development returned 356 results
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Malvern Instruments Mastersizer 3000 particle size analyzer new software speeds method development
New software for the Mastersizer 3000 laser diffraction particle size analyzer from Malvern Instruments continues to lighten the analytical workload associated with developing robust particle sizing methods for industrial applications. Smart new operational features, such as an Optical Property Optimizer, simplify and streamline the process of method development, while a new result emulation tool eases the process of transferring methods from other particle sizing techniques. A growing range of integrated visual guides, covering every aspect of the operation of the Mastersizer system, provide the reassurance of Malvern expertise at the bench top.. Laser diffraction systems offer highly automated, easy-to-use, ‘push-button’ particle sizing for diverse applications across industry. However, reaching this level of analytical efficiency requires careful development of a suitable measurement method. The new Mastersizer 3000 v3.00 software simplifies this by aiding users in selecting optical properties - one of the last-remaining expert tasks in laser diffraction. The new version software also supports method transfer, helping laboratories to reach new levels of productivity.. The new Optical Property Optimizer (OPO) allows users to easily manipulate the optical properties necessary to calculate particle size distributions from laser diffraction data, helping them to experimentally determine the ideal settings for a given application. Use of the OPO is explained in an embedded video, which joins the growing series of walkthrough tutorials covering all aspects of laser diffraction analysis for both wet and dry dispersion measurements. Clearly presented and easy to understand, the new video mini-guides provide expert support at the instrument, maximizing productivity. Finally, efficiency of a lab can be further enhanced through the application of a new emulation tool that eases method transfer between alternative sizing techniques, such as sieving and laser diffraction. This helps to ensure successful application of a method when upgrading to laser diffraction and allows direct comparison with historic particle sizing data.. The Mastersizer 3000 laser diffraction particle size analyzer delivers precise, robust measurement of dry powders and liquid dispersions across the milli-, micro- and nano-meter size range, with an extended dynamic range that spans 0.01 to 3500 microns. The new software advances the capabilities of the laser diffraction user interface, supplying those with limited experience of particle sizing with the support needed to confidently access the full capabilities of the Mastersizer system.. For more information on how Malvern Mastersizer 3000 family visit the particle sizing webpages on the Malvern website at http://www.malvern.com/mastersizer3000. Malvern, Malvern Instruments, Mastersizer are registered trademarks of Malvern Instruments Ltd.
Application of QbD to analytical method development for particle size distribution measurements
The last decade has seen a shift within the pharmaceutical industry towards Quality by Design - a risk-based approach to the development and manufacture of pharmaceutical products. This adoption of QbD has led to it being applied to analytical method development, where the process of identifying critical method parameters and understanding a method's design space provides significant benefits to users in developing appropriate, robust measurement procedures. In this webinar we introduce how QbD can be applied in the case of particle size analysis, considering the requirements for both liquid and dry powder dispersion.
Masterclass 2: Developing wet or liquid dispersion methods using laser diffraction
This webinar will cover method development for samples dispersed in liquids. This will include a discussion of factors affecting the measurement, such as sampling and dispersion, and the relative importance of these factors in different particle size ranges. We will then suggest some routes that you can follow to develop robust methods for laser diffraction measurements in wet dispersion.
Beyond SOPs – Exploring the rigor and requirements of Analytical QbD
Analytical QbD (AQbD) promises to extend the rigor and benefits of QbD into the area of analytical method development. Here, Paul Kippax provides an introduction to the methodology involved and takes as an example the application of AQbD to the development of a laser diffraction particle sizing method. .
Dry nasal powders: a new analytical challenge?
While there are sound commercial and technical drivers for adopting dry nasal spray technology, its development relies on identifying supportive analytical protocols. Can the methods applied to liquid nasal sprays aid development of this technology?
New accessories for the Mastersizer 3000 support smarter pharmaceutical particle size analysis
New ‘third anniversary’ accessories for the Mastersizer 3000 from Malvern Instruments reduce the time and cost of developing and validating robust methods for pharmaceutical particle size analysis. Correlations between particle size and bioavailability make particle size analysis a critical activity for the pharmaceutical industry. The innovative lens-less Hydro Sight imaging accessory enables real-time visual monitoring of a dispersion, providing information to swiftly optimize and validate a method. The Hydro SV (small volume) cell allows method development and reliable particle size analysis, with just a few milliliters of sample.. “In combination these accessories considerably ease the burden associated with routine particle sizing within the pharmaceutical industry”, said Dr Paul Kippax, Pharmaceutical Portfolio Manager for Malvern Instruments. “Developing, validating and transferring particle sizing methods efficiently and cost-effectively is essential for this sector. Hydro Sight provides unprecedented insight into the effectiveness and consistency of a particle sizing method. The Hydro SV, on the other hand, enables detailed method development when there are only scant, highly valuable amounts of material available. Used together the accessories support a QbD approach from the very earliest stages of drug development.”. A key step in laser diffraction particle sizing is to achieve appropriate dispersion. This ensures that the measured particle size is representative of the sample and relevant to the application. Hydro Sight is a cutting-edge accessory that images particles in real-time, as they undergo wet dispersion in the analyzer. Measurements of size and shape (elongation) distribution in combination with a unique ‘dispersion index’ provide continuous insight into dispersion behavior and confirm the consistency and completeness of the dispersion process. An advanced anomaly detection function automatically records images of outlying particles, those that are unusual in terms of size and/or shape. The resulting information cuts the cost and time associated with method development, analytical troubleshooting, method validation and the transfer of analytical techniques from R&D through to QC.. For more information on Hydro Sight, register to view Malvern’s launch web event at http://www.malvern.com/msevent or visit www.malvern.com. Malvern, Malvern Instruments and Mastersizer 3000 are registered trademarks of Malvern Instruments Ltd.
Particle Sizing Masterclass 3: method development
In this third webinar in the particle sizing masterclass we look at method development and we concentrate on the techniques of laser diffraction and automated image analysis. The most important thing in method development is always to make sure that the results enable you to follow your production process or understand your product’s performance. With that in mind we look at how to work out how much sample you need to measure, the different options available for dispersing the sample (and how you might choose the best one for your sample) as well as how to set the appropriate measurement conditions. We use a couple of case studies to illustrate these three main factors, and after that you should have a good idea of how to start developing methods for your materials.. Why attend? . To learn about method development for laser diffraction and automated image analysis. . To find out about the different ways of dispersing particles and how to choose the best one for your application. . To get some ideas for how to get started with method development..
Advanced Triple Detection GPC of High Molecular Weight Polyacrylamide Resin
Polyacrylamide resins have traditionally been difficult to analyze by conventional chromatographic methods due to their high polarity, structural inconsistencies, and hydrogen bonding capabilities. A specialized method has been developed
Imaging Masterclass 2: Sample preparation techniques for particle size and shape measurements
For successful sample characterisation by image analysis, as with any other analytical technique, good sample preparation is critical. In this webinar we will discuss best practise in method development and describe a number of dispersion methods for dry powders and wet suspensions.
Issues in the appraisal of laser diffraction particle sizing techniques
Thie article discusses the main issues associated with the use of laser diffraction particle size analysis and how these can be overcome during the development of particle sizing methods.
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