Date recorded: July 02 2014

Duration: 30 minutes 34 seconds

The accurate size measurement of both large and small therapeutic molecules within formulations has long been considered a challenge, complicated by the presence of excipient molecules and high background "noise". Malvern's Viscosizer 200 can see through these complications to measure only the molecules of interest, both accurately and repeatedly. During this webinar, data are presented to describe the analysis of molecules in formulations containing different excipients as well as the detection of conformational changes in proteins. In addition, the presentation covers the use of microcapillary viscometry to assess viscosity and potential deliverability issues which the technique is able to highlight in preformulation and early formulation development.

Table of contents
1. A new approach to improving early characterization of therapeutic formulations - Viscosizer 200
00:55
2. A new approach to improving early characterization of therapeutic formulations:Microcapillary flow and Taylor Dispersion Analysis
00:30
3. Introduction
00:45
4. Introduction
00:03
5. Introduction – Viscosizer 200
01:33
6. Introduction – Viscosizer 200
00:45
7. System Overview
00:18
8. Capillary
00:23
9. Measurements
00:12
10. Sizing
00:49
11. Size Measurements
00:45
12. Size Calculation
00:32
13. Taylor Dispersion Analysis
00:30
14. Taylor Dispersion Analysis
00:21
15. Measurements
00:06
16. Viscosity
00:39
17. Viscosity
00:16
18. Viscosity Measurements
01:00
19. Viscosity Calculations
00:31
20. Applications
00:19
21. Applications
00:13
22. Sizing of Small Molecules
00:45
23. Sizing of Small Molecules
01:04
24. Sizing proteins in the presence of large aggregates
00:51
25. Taylor Dispersion Analysis
03:10
26. Sizing Proteins in the Presence of Excipients
00:19
27. Sizing Proteins in the Presence of Excipients
00:15
28. Sizing Proteins in the Presence of Excipients
00:23
29. Sizing Proteins in the Presence of Excipients
00:20
30. Sizing Proteins in the Presence of Excipients
00:32
31. Applications
00:09
32. Comparative studies: monitoring protein change
00:18
33. Comparative studies: monitoring protein change
00:42
34. Applications
00:17
35. Biotherapeutic Viscosity
01:04
36. Effect of excipients on BSA formulation viscosity
01:04
37. Screening formulation viscosity
00:42
38. Viscosity measurements of non-UV active molecules
01:16
39. Summary
00:56
40. Thank You Any Questions?
04:11
41. Contact Information
00:51