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Application notes describe the application of one or more of our analytical methods to resolve issues or answer questions.

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DSC is an established analytcal tool used during process development and manufacturing of biopharmaceuticals. Rank ordering of thermal transition midpoints (TMs) and other parameters from DSC is commonly used to screen process conditions like buffers, pH and ionic strength. The typical correlation is the higher the TM, the more stable the protein is and less likely to aggregate. DSC is also used as a comparability assay to make sure different lots of the the same protein drug are "highly similar" in thermal stability.

Products:
MicroCal PEAQ-DSC
Date:
September 20 2016
Language:
English

Dynamic Light Scattering (DLS) is a mature and proven technology for nanomaterial characterization. Nanoparticle Tracking Analysis (NTA) is a more recent addition to the spectrum of particle characterization techniques and has many similarities to DLS, leading to some confusion as to their relative capabilities. The broad range of measurement capabilities for each technique is complementary in nature, providing a wealth of valuable information. The differences between the two techniques allow the data from one technology to validate and support the other.

Products:
Zetasizer Nano range
Date:
November 23 2016
Language:
English

DSC is an established analytical tool used for higher order structure (HOS) comparability studies of biopharmaceuticals, and for HOS analysis during development of biosimilars. Comparison of DSC thermograms from a reference protein with a new batch of the protein is used to assess the similarity of the conformational stability of the two proteins. Comparability studies are also performed if there is a process change, to ensure the change does not affect protein stability. DSC is also utilized as an analytical tool during the development of biosimilars, where DSC thermograms for the biosimilar are compared to the parent (innovator) drug product.

Products:
MicroCal PEAQ-DSC Automated
Date:
December 1 2016
Language:
English

International standard ISO16332 Diesel engines — Fuel filters — Method for evaluating fuel/water separation efficiency (the US equivalent being SAE J1488) is currently undergoing revision and its publication is imminent. This new version standardizes the testing of filters between manufacturers and looks at the effectiveness of the test rig and how potential droplet recirculation could affect particle size distribution (PSD). It outlines testing of filter efficiency and gives a model particle size distribution for this. Laser diffraction is specified in the standard as the only method for sizing this distribution. This white paper examines how laser diffraction particle sizing, already an established tool in fuel filter testing, is stepping up to the challenges posed by modern fuels and the latest testing requirements. We consider the technique’s application within the context of the new methods being written for ISO16332, focusing on its implementation for measurements at high concentration, high pressure and high flow rates.

Products:
Insitec range
Date:
March 24 2017
Language:
English

This datasheet demonstrates that the Epsilon 1, a benchtop energy dispersive X-ray fluorescence spectrometer, is more than capable of analyzing major, minor and trace elements in ceramic nanomaterials, in an easy and non-destructive way. In the production of nanomaterials, catalysts are often used to enhance the formation of particles smaller than 100 nm. Nanomaterials are being used in many new applications. These include healthcare, composite materials, electrical and many other applications.

Products:
Epsilon 1 Research and education
Date:
July 27 2017
Language:
English

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