In some industries, for example, in early-stage pharmaceutical development, it is desirable to measure particle size from a small samples of dry powders. However measuring small quantities risks measuring a sample that is not representative of the bulk material. In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.