Spotting the weakest binders: weak binders, strong data

Employing our Grating-Coupled Interferometry (GCI) technology to deliver superior sensitivity over traditional Surface Plasmon Resonance (SPR) technologies, researchers can reliably determine off-rates of up to 10s^-1, starting with just a crude reaction mixture. Combined with microfluidics that sustain a wide variety of solvents - including acetonitrile and high concentrations of DMSO -, the occurrence of false positives is minimized.

• Screen, rank and characterize weak binders with off-rates up to 10 s^-1
• Study binding kinetics even at large analyte:ligand MW ratios (up to 1:1000)
• Experiment with crude mixtures, detergents and other additives without clogging