DSC is an established analytical tool used during preformulation and formulation development
of biopharmaceuticals. Rank ordering of thermal transition midpoint (TM) by DSC is commonly used to screen formulation buffers, pH and excipients. Typicallly, the higher the TM, the more stable the protein in that formulation, and less likelihood of aggregation. This whitepaper gives examples on the use of DSC in formulation development.