The physical components and features of a Differential Scanning Calorimeter (DSC) and the technical specifications are important to consider when purchasing a new system. However, written specifications can be confusing, and may actually have little bearing on the actual performance of the instrument. Specifications, on paper, do not necessarily translate into advantages or disadvantages when it comes to making measurements on your samples. The best components and technical specifications in the world do not matter if the instrument is not assembled or optimized in a way that translate into real improvements in data quality and ease of use when you are working with your samples. This document outlines some questions you should ask yourself as you begin evaluating Differential Scanning Calorimeters.