Date recorded: August 25 2021

Viral vectors are increasingly being used to develop therapeutics and vaccines for which genetic information forms the active ingredient. This method utilizes the efficiency with which viruses deliver genetic information to cells they infect to produce an effective delivery system.

Incorporation of therapeutic or antigenic genetic information into inactive viral capsids, therefore, gives a highly effective means of getting such therapies to their target. Understandably, it is key to ensure the proper insertion of the active genetic information into the vectoring capsids. It is also very important to optimize the stability of viral vectors, ensuring their integrity (and the retention of their cargo) during processing and storage.

In this webinar, the use of multi-detection SEC (MALS) as a sensitive, label-free means of accurately quantifying the success of viral capsid-loading procedures will be discussed – essential information to anyone seeking to optimize the loading process and monitor cargo-retention further along the workflow. The use of the same method to monitor capsid aggregation will also be elaborated on, as will the use of DSC as a tool for optimizing and proving capsid/formulation stability.

So if you are interested in understanding the tools at your disposal for optimizing the efficacy and stability of gene therapy products, please do register and join this session, which will include a Q+A session to answer any questions you may have.

Join our free MasterClass series on gene therapy and viral vectors analysis

- Webinar 1: Comprehensive viral vector characterization: The value of rapid label-free biophysical techniques. More info

- Webinar 2: Quantifying rAAV and other viral vector quality attributes with Multi-angle DLS and nanoparticle tracking analysis. More info

- Webinar 3: Optimising loading time and stability of Virally Vectored therapies and vaccines using SEC and DSC