How multi-detector GPC/SEC can advance our understanding of drug delivery polymers

Log in to watch this webinar

Not registered yet? Create an account
00:00:00 Welcome
00:00:11 Introduction
00:01:48 Gel-permeation chromatography
00:02:22 Multi-detector SEC
00:03:12 RI Detection
00:03:41 UV Detection
00:04:26 Static Light Scattering – Molecular Weight
00:05:55 How does intrinsic viscosity relate to structure?
00:07:52 What are the Multiple Detectors responding to?
00:08:39 The multi-detection pyramid
00:10:35 SEC & Triple Detection Summary
00:11:04 PLGA
00:11:27 PLGA
00:13:51 PLA
00:15:39 PLGA 50:50
00:16:08 PLGA 50:50 - 8 repeat injections
00:16:55 PLA/PLGA copolymers
00:18:46 PLA/PLGA
00:20:21 PLA/PLGA
00:21:29 Solvent compatibility
00:23:40 Solvent compatibility
00:24:05 Solvent compatibility
00:25:12 Drug delivery application: Polyglutamate and Doxorubicin
00:25:20 Drug Delivery – Polyglutamate & Doxorubicin
00:26:53 PG
00:27:14 PG & PG-Dox overlays
00:28:29 Doxorubicin concentration calibration curve
00:29:11 Conjugate Dox content
00:30:43 Molecular weight
00:31:42 Polymer and conjugate structure
00:33:43 Summary
00:34:42 Thank you for your attentionAny questions?Please type your questions in using the Q&A panel on the right side of your screen
00:41:38 Contact Information
Correctly targeting a drug product’s delivery location and defining its release profile are critical challenges and the subject of a great deal of research. The role of polymers in drug delivery applications is growing, with particular emphasis on targeted controlled-release mechanisms and the development of nanoparticles used to contain or carry drug molecules.

This presentation focuses on the information provided by GPC/SEC about polymers used in drug delivery applications. In the case of polymer conjugates, GPC/SEC can also be used to characterize the end-product; for example, by measuring the amount of drug conjugated to the polymer.

The webinar includes a short overview of GPC/SEC technologies used to make these measurements and covers some key application examples showing the technology’s utility. Mark also explains how DLS can be used to characterize nanoparticles made for drug delivery applications and how these two techniques together can accelerate research in this key application area.