XRD Solution for Pharmaceutical Powder Analysis: Characterizing Solid Drugs with Aeris X-ray Diffractometer (XRD)
Pharmaceutical industry considers powder form solid drugs as crucial factors determining quality, stability, and efficacy.
In particular, the drug’s crystalline structure and solid state have a direct impact on the solubility, bioavailability, and storage stability of the final product.
For these reasons, accurate and reliable analysis of pharmaceutical powders is essential.
This article introduces Malvern Panalytical’s Aeris X-ray Diffractometer (XRD) , the best solution for the pharmaceutical industry.
Discover how to quickly and easily characterize the structure of solid drugs through XRD analysis!
Why XRD Analysis is Needed in the Pharmaceutical Industry
During the development process of solid dosage forms, the following issues frequently occur:
- Diverse polymorphs of the active pharmaceutical ingredient (API)
- Assessment of crystallinity and amorphous content
- Formulation stability evaluation
- Monitoring crystalline structure changes during the process
All these analyses can be performed quickly and accurately through X-ray diffraction analysis (XRD Analysis).
In particular, regulatory agencies (like the FDA, EMA, etc.) require solid-state characterization data during new drug approval processes.
Aeris XRD: The Perfect Solution for Pharmaceutical Powder Analysis
1. Compact and Efficient Design
Aeris is a benchtop (compact) XRD device, which can be directly connected to standard power without additional cooling water supply.
This allows for easy installation and operation without space constraints, even in pharmaceutical laboratories.
2. Pharmaceutical-Tailored Modes
Aeris offers analysis modes specially developed for the pharmaceutical industry.
Notable features include:
- Solid State Analysis
- Crystallinity Assessment
- Phase Identification and Quantification
It is particularly advantageous for its user interface designed to be intuitive even for beginners.
3. Fast and Accurate Data
Aeris provides high-quality data quickly with advanced optics and detection systems.
- Short analysis time
- Highly reliable results
- Minimization of human error through automation
This ensures optimal performance not only for research and development (R&D) but also for quality control (QC).
Major Pharmaceutical Analysis Functions Offered by Aeris XRD
| Analysis Item | Application of Aeris XRD |
|---|---|
| API Polymorph Analysis | Distinction of various polymorphs |
| Crystallinity Assessment | Crystallinity/amorphous ratio analysis of API and formulation |
| Solidification Property Study | Prediction of drug stability and solubility |
| Production Process Monitoring | Real-time monitoring of crystalline structure changes during manufacturing |
Benefits of Aeris XRD for the Pharmaceutical Industry
- Strengthened Regulatory Compliance: XRD data can be utilized in regulatory document submissions to FDA, EMA
- Cost Savings: Quick installation and maintenance without additional infrastructure
- Improved Quality: Enhanced Quality by Design (QbD) strategies for formulations
- Accelerated Processes: Speed up new drug development
Powder analysis is key to the success of pharmaceutical products.
Aeris XRD helps quickly and easily identify the characteristics of solid drugs.
From pharmaceutical R&D to QC, Aeris will be a dependable partner.
See More Related Resources
- Download detailed application notes: Pharmaceutical formulation analysis through XRD – Antibiotics, anti-inflammatory analgesics
- Online lecture: Stability studies through in situ XRD
- Journal article: In-situ investigation of solid phase evolution during lyophilization of mannitol-based antibody formulations using an XRPD climate chamber
- Related Korean Pharmacopoeia General Experimental Method Seminar: May 14 at Osong kbio Communication Center
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