Combined pump, degasser, autosampler and column oven, for high quality GPC/SEC and accurate molecular weight measurement.

OMNISEC RESOLVE combines with OMNISEC REVEAL to form a complete OMNISEC GPC/SEC solution for the measurement of absolute molecular weight, intrinsic viscosity and other parameters. It combines an integrated pump, degasser, autosampler and column oven in a single advanced separations unit.

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OMNISEC RESOLVE has been designed using our 30 years of experience in GPC/SEC to achieve the highest possible standard in chromatographic performance. The efficient degasser, low-pulsation pump and column oven combine to give reduced baseline noise, which maximizes measurement sensitivity and accuracy.

Fully integrated into the OMNISEC software and hardware platform to offer a complete GPC/SEC solution from a single vendor. 
Combined pump, degasser, autosampler and column oven in a single module.

  • All components of the OMNISEC system are designed and manufactured by Malvern Panalytical to ensure their complete optimization for delivering full sample characterization
  • RESOLVE is designed uniquely for GPC/SEC separations, meaning it is focused on delivering optimal performance without compromises
  • User training is improved with only a single unit and operating system to learn
  • Single point of contact for support and service requirements

Improved detector baseline stability with a Low pulsation pump and efficient degasser. 

  • This powerful combination of pump and degasser offers fantastic flow rate stability which results in excellent detector signals in the REVEAL
  • Improving detector signal stability directly allows you to measure lower concentration, lower molecular weight samples

Rapid solvent change overs with a low volume degasser giving maximum system productivity. 

  • The highly efficient low volume degasser is just 960µl! This enables the rapid solvent change overs without compromising performance

Reduce sample usage with low injection volumes and waste-free injections from vials or 96-well microtiter plates

  • We know how precious your samples are and nobody wants to waste them unnecessarily
  • Using the zero-waste injection mode all the samples will be loaded onto the column for maximum sensitivity with zero waste
  • If you prefer using a standard partial loop or full loop injections these options are still available and user-selectable
  • Inject samples from either standard SEC vials or microtiter plates to maximize system flexibility and productivity

Temperature controlled Autosampler (4oC – 60oC) to protect thermolabile samples.
Make separations in viscous solvents such as DMF and DMSO thanks to the column oven and autosampler temperature control.

  • All systems include a complete temperature control range as standard, no need to budget for additional extras
  • Whether your samples will degrade at high temperatures or will drop out of solution when not at elevated temperatures, OMNISEC delivers the complete separation chain as an actively temperature-controlled environment
  • Temperature control ensures optimal baseline stability and, importantly, that your sample arrives at the detectors in the best condition

Reduce service requirements thanks to continuous pump seal backwashing

  • Solvent is continuously flushed over the back seals in the SEC pump washing away any precipitate that may accumulate to reduce wear on pump components
  • Get maximum system uptime by reducing service requirements

How it works

In SEC/GPC molecules are separated according to their hydrodynamic volume as they enter and exit the pores of a porous gel packing matrix in the column. Like other HPLC-based techniques, this involves the use of a pump, column and at least one detector to measure the sample as it elutes. 

OMNISEC RESOLVE is a fully optimized and dedicated SEC/GPC system that offers market leading performance.



  • Rapid mobile-phase exchange thanks to low volume degasser


  • Rapid mobile-phase exchange thanks to self-priming pump
  • Reduced service requirement thanks to novel continuous back seal flushing mechanism


  • Protect samples from aggregation with autosampler temperature control
  • Use your preferred sample format; vials or 96-well microtiter plates
  • Reduce sample use with zero-waste mode


Column Oven

  • Temperature control of up to 6 analytical columns




Pump flow rate 0.01 - 10 mL/min
Flow rate accuracy ±1%
Pressure range 0 - 5000 PSI (34.5 MPa)
Pulsation 0.15% @ 1 mL/min in water
Dimensions (W, D, H) 420, 640, 890 mm
Weight 62 kg
Software OMNISEC software v10 (or later)
Data acquisition rate 100 Hz


Capacity Up to 192
Sample container types HPLC vials or 96-well microtiter plates
Injection volume 1 - 300 µL
Injection volume precision

<0.3% RSD in full loop mode

<0.5% RSD in partial loop mode

<1% RSD in µL pickup mode

Injection overhead volume 0 µL in µL pickup mode
Syringe volume 250 µL standard
Temperature control range 4 - 60 °C

Column oven

Column capacity 6 x analytical (1 x Tricorn 10/300 GL)
Temperature control range 20 - 65 °C

Operating environment

Temperature 15 - 30 °C