OMNISEC RESOLVE has been designed using our 30 years of experience in GPC/SEC to achieve the highest possible standard in chromatographic performance. The efficient degasser, low-pulsation pump and column oven combine to give reduced baseline noise, which maximizes measurement sensitivity and accuracy.


  • Achieve superior baseline stability in all detectors with its efficient degasser and pump flow rate stability
  • Reduce sample usage with low injection volumes and waste-free injections from vials or 96-well microtiter plates
  • Protect thermolabile samples such as proteins from aggregation in the cooled autosampler
  • Rapidly switch between many applications, solvents and buffers, thanks to its efficient, low-volume degasser and automated pump priming
  • Make separations in viscous solvents such as DMF and DMSO thanks to the column oven and autosampler temperature control
  • Reduce service requirements thanks to continuous pump seal back washing

GPC/SEC is a two-step analytical process that involves separating a sample on the basis of its size and then analyzing the resulting fractions. The technique delivers molecular weight, molecular size and structural information, all of which define the performance of many industrially important materials. Coupling the efficient sample separation of OMNISEC RESOLVE with the fully optimized, multi-detector, information-rich analysis delivered by OMNISEC REVEAL, Malvern has produced a market-leading solution for researchers and formulators developing novel natural and synthetic polymers, pharmaceutical and biopharmaceutical products and foods.


Pump flow rate:
0.005 - 10 mL/min
Flow rate accuracy:
Pressure range:
0 - 5000 PSI (34.5 MPa)
0.15% @ 1 mL/min in water
Dimensions (W, D, H):
420, 640, 890 mm
62 kg
OMNISEC software v10 (or later)
Data acquisition rate:
100 Hz
US 14/599,033 "Continuous back seal wash"


Up to 192
Sample container types:
HPLC vials or 96-well microtiter plates
Injection volume:
1 - 300 µL
Injection volume accuracy:
Injection volume precision:

<0.3% RSD in full loop mode

<0.5% RSD in partial loop mode

<1% RSD in µL pickup mode

Injection overhead volume:
0 µL in µL pickup mode
Syringe volume:
250 µL standard
Temperature control range:
4 - 60 °C

Column oven

Column capacity:
6 x analytical (1 x Tricorn 10/300 GL)
Temperature control range:
20 - 65 °C

Operating environment

15 - 30 °C


Minimum computer specification:
Windows 7 Professional 64 bit, 4th Gen Intel(R) Core I7 Processor (Quad Core HT, 3.4 GHz Turbo, w/ HD Graphics), 8 GB 1600 MHz DDR3 memory, 500 GB 3.5 inch SATA (7200 RPM) HDD, Full-HD monitor