Manuals and software

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MicroCal PEAQ-DSC instruments provide value to a wide range of applications, some of which are outlined below.

Protein Characterization 

MicroCal PEAQ-DSC is a fundamental tool for characterizing proteins. Key questions such as;

• Is my protein folded?

• In what conditions is my protein stable?

• Is the protein multi domain?

• Does my protein bind a ligand or cofactor?

can all be answered in simple DSC experiments.

The Power of Heat: Digging Deeper with Differential Scanning Calorimetry to Study Key Protein Characteristics 

Value of DSC in characterization and optimization of protein stability as compared to other thermal stability assays


Biotherapeutic Discovery, Development and Manufacturing

The MicroCal PEAQ-DSC Automated is trusted throughout the biopharmaceutical industry to provide valuable stability data for biotherapeutics in discovery, development and manufacturing. This is because of the universal nature of the detection method, the ability to detect very subtle changes in the conformation of biologic drugs and the high reproducibility of the data. 

Solve stability problems in preformulation and process development using DSC 

Use of microcalorimetry and its correlation with Size Exclusion Chromatography for rapid screening of the physical stability of large pharmaceutical proteins in solution 

Using Differential Scanning Calorimetry to accelerate liquid formulation development for protein biopharmaceuticals 

Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in biopharmaceutical formulation development 

Using DSC to investigate the impact of oxidation on protein structure 

Using Differential Scanning Calorimetry (DSC) to optimize antibody manufacturing 

Biosimilarity and Biocomparabilty

The highly reproducible nature of the MicroCal PEAQ-DSC instruments and the ability of the technique to detect even changes to a single amino acid in a protein have been the core drivers behind the use of DSC data in submissions for approval for biosimilar drugs. The MicroCal PEAQ-DSC software has a biosimilarity tool for statistical comparison with the innovator drug.

Characterization of biopharmaceutical stability with Differential Scanning Calorimetry: Biosimilarity and batch-to-batch comparability

Liposomes

Liposomes are used as model membrane systems and as potential drug delivery systems. ‘Structure Activity Relationships’ (SAR) of membrane components and drug uptake into a liposomes can be investigated monitoring shifts in the phase transition temperatures and enthalpies measured by DSC. Indeed, any material that forms micelles or other macromolecular structures can be studied using the technique.

Good practice for studying the stability of liposomes, their use as model systems and in drug delivery

Using DSC to characterize thermotropic phase transitions in lipid bilayer membranes: The basics of liposome sample preparation and DSC studies

Characterization of Antibody Drug Conjugates and Vaccines

DSC, DLS and other biophysical technique can be used to study the stability of Antibody Drug Candidates and the effects of antibody drug ratios on their stability and propensity to aggregate. The example below also show how DSC can be used to measure the kinetics of inactivation by heating over a broad range of scan rates.




Contact support

Events and training

Sdl.Web.Common.Models.Tag MicroCal DSC User Training - May
Date:
May 14 2019 - May 15 2019
Time:
13:00 - 20:00
(GMT-05:00) Eastern [US & Canada]
Location:
@Model.Country
Event type:
Classroom based training
Language:
English