| 00:00:00 | Laser diffraction masterclass 5: Setting specifications |
| 00:00:51 | Masterclass 5: Specification setting |
| 00:01:19 | Laser diffraction measurement process |
| 00:02:03 | Laser Diffraction Masterclass |
| 00:02:26 | Overview |
| 00:03:35 | What is a specification? |
| 00:04:52 | What properties should be considered? |
| 00:05:39 | When should particle size be measured? |
| 00:07:48 | How should specifications be justified? |
| 00:08:30 | What should specifications be based on? |
| 00:10:53 | Understanding the results from a diffraction system |
| 00:13:01 | Typical laser diffraction results |
| 00:13:29 | Distribution statistics: Median and mode |
| 00:13:50 | Distribution statistics: Median and mode |
| 00:14:38 | Distribution statistics: Percentiles |
| 00:15:38 | Distribution statistics: Percentiles |
| 00:16:16 | Distribution statistics: Mean particle sizes |
| 00:16:53 | Distribution statistics: Mean particle size |
| 00:18:04 | Distribution statistics: Mean particle sizes |
| 00:18:48 | Distribution statistics: Sampling requirements |
| 00:18:53 | Distribution statistics: Sampling requirements |
| 00:20:00 | Definitions of measurement precision |
| 00:21:39 | What precision values are reasonable? |
| 00:23:15 | Setting a specification: Dissolution dynamics |
| 00:25:08 | Controlling the dissolution rate |
| 00:26:04 | Controlling the dissolution rate |
| 00:26:48 | Tracking changes in particle size |
| 00:28:25 | Controlling formulation stability: sedimentation |
| 00:29:23 | Controlling suspension rheology |
| 00:29:57 | How does particle size affect suspension rheology? |
| 00:30:02 | Factors affecting the tableting process |
| 00:30:54 | Forces of adhesion as a function of particle size |
| 00:31:38 | Specification example: Tablet formulation |
| 00:32:29 | Specification example: Tablet formulation |
| 00:33:59 | Specification example: Tablet formulation |
| 00:36:21 | Linking measurement data and manufacturing specifications |
| 00:37:07 | Conclusions |
| 00:38:29 | Questions |
| 00:43:07 | Thank you |
| 00:43:46 | Upcoming webinars |
In this webinar we look at the particle size distribution data generated by laser diffraction, and consider how these can be used to generate realistic product specifications.