The term ‘epigenetics’ refers to changes in and regulation of gene expression and function, without alteration of DNA sequence. The mechanisms behind these changes involve “epigenetic regulator” proteins that interact with and modify chromatin (DNA wrapped around histone proteins).

Epigenetic regulators and their interactions with histones or DNA are of growing interest to the life science research community, as they play an important role in many biological processes, and contribute to human diseases such as cancer and inflammation.

There are many current drug discovery projects looking for small molecules which can inhibit epigenetic regulators. This webinar will present an overview of how isothermal titration calorimetry (ITC) can be used to characterize the binding affinity and thermodynamics of epigenetic interactions, based on recent publications.

The presentation will also discuss how ITC is used to push forward small molecule drug discovery of epigenetic targets.