System Validation with Latex and QAS Sample

by Seungji Kim, Friday, 22nd May 2015

System Validation with Latex and QAS Sample
< Standard Latex and QAS Sample for Diffraction System Validation >


• Why should we measure using Standard Samples?
Different Latex Sizes scatter Laser differently, which allows verification of the performance of different detectors inside the equipment.
QAS (Quality Audit Standard) Sample is a standard sample with a particle size distribution of about 10~100um, which can be used to check the entire range of the Diffraction system.

• When is the measurement of Standard Samples necessary?
While regular validations (annually) are recommended during equipment use, irregular or short-term self-validation within a year can be done using Latex Sample or QAS (Glass Beads) to check equipment condition.

• What types of Standard Samples are there?
< Standard samples for ISO 13320-1 compliance >
  – Standard sample for small volume dispersion devices (QAS 3001B)
  – Standard sample for wet and dry dispersion devices (QAS 3002)
<Standard sample for nano particle size verification>
  – 60/200 nano particle size standard sample (LTX3060A/LTX3200A)
<Standard sample for zeta potential verification (DTS 1235)>

Check out more Standard materials >

 
• Limitations of Self-Standard Sample Test
For verification, a dedicated dispersion device for measuring standard samples is required to avoid verification failure due to contamination of the dispersion device. If the measurement of the standard sample is outside the set range, problems can be solved by removing contamination from the equipment and dispersion device, but severe contamination inside the equipment or output degradation due to Laser aging requires contamination removal and equipment calibration, in which case a Malvern engineer must visit in person to calibrate and verify the equipment.
< Why is periodic verification of the particle size analyzer necessary? >


• Why is periodic verification of the particle size analyzer necessary?
The main body, made of optical parts and electronic components along with Laser, performs calculations to change the distribution of Laser diffraction energy into particle size. Over time, due to contamination, Laser output degradation, etc., it gradually changes the light amount, affecting the particle size distribution.
In this case, periodic contamination removal, calibration, etc. should be carried out to obtain accurate data.

• How is the verification of the particle size analyzer conducted?
Verification of a Laser diffraction particle size analyzer adheres to ISO13320, measuring internationally certified NIST Latex Standard to verify if the equipment can show the defined particle size distribution.
If the measurement result is out of range and verification fails, the equipment is recalibrated, and checked again to see if the standard sample measurement result is within the predefined range.
Check out Malvern’s calibration solutions >
< Accurate and Convenient Malvern Calibration Service >
Malvern’s calibration service offers the best services provided by experienced professionals at a fixed cost. By signing an annual maintenance contract, you can receive top-priority response services and minimize the time the equipment remains unused due to potential equipment malfunctions.

– PV (Performance Verification)
• Performance check and maintenance using standard materials
• Issuance of Verification Certificate

– OQ (Operation Qualification)
• PV + Issuance of Verification Certificate
• Provision of Certified OQ Document

– Service Contract (Platinum/Gold Contact)
• Convenient equipment management, education, inspection, and calibration services
• Free on-site repair costs
• Free replacement of parts (Platinum Service)

 

Check out Malvern’s calibration solutions >

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