Screening of crude reaction mixtures

In this technical note we show how the Creoptix WAVE provides a reliable environment to support optimization of hits in fragment-based drug discovery. With high sensitivity and robust microfluidics, the WAVEsystem offers kinetic data in excellent agreement with Biacore T200 measurements. This is illustrated through a retrospectively measured Vernalis campaign to identify selective, potent inhibitors of Pyruvate Dehydrogenase Kinase 2 (PDHK2) and Heat Shock Protein 90 (HSP90).

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