Knowledge Center

Calibrate your instruments. Troubleshoot a problem. Find out what that button really does. We have answers.

207 results

Sort search results by or

Page 1 of 21
Article

13 December 2021 | English

How Malvern Panalytical helps enable additive manufacturing breakthroughs

Additive manufacturing (or AM) is fast taking off as a way to produce a wide range of components more efficiently, sustainably, and cost-effectively. John Duffy, Sector Marketing Manager for Advanced Materials, shares his views on what the additive manufacturing world looks like today, what it might look like in future, and how Malvern Panalytical helps make that future a reality. Please login or register for free to read more.

Products:
Zetium
Industry:
Advanced Manufacturing
How Malvern Panalytical helps enable additive manufacturing breakthroughs
Article

13 December 2021 | English

How Malvern Panalytical enables battery manufacturing innovation

Battery power is increasingly being recognized as a viable option for sustainable energy storage and electric transportation. Umesh Tiwari, Global Manager for Advanced Materials and an expert in batteries and renewable energies, discusses the current battery landscape, the future of battery technologies, and the solutions Malvern Panalytical can provide. Please login or register for free to read the full article.

Products:
Mastersizer 3000
Technology:
X-ray Fluorescence (XRF)
Industry:
Fuel cells
How Malvern Panalytical enables battery manufacturing innovation
Article

03 December 2021 | English

A controlled blend

This article introduces an energy dispersive X-ray fluorescence (EDXRF) spectrometer for on-line elemental analysis in liquid process flows: Malvern Panalytical’s Epsilon Xflow. This technology enables the user to analyze, control and steer liquid-based production processes in real time, thereby optimizing production processes and blending operations. The analytical performance of the on-line spectrometer is demonstrated using two applications: on-line monitoring of the sulfur concentration in diesel to meet sulfur concentration levels prescribed by Euro VI, China VI, Bharat Stage VI, Tier 3 regulations, and the analysis of catalysts poisons in hydrotreating and fluid catalytic cracking (FCC) processes.

Products:
Epsilon Xflow
Technology:
Energy Dispersive X-ray Fluorescence (EDXRF)
Industry:
Oils, Fuels and Chemicals
A controlled blend
Article

17 June 2021 | English

Characterization of Recombinant Adeno-Associated Viruses (rAAVs) for Gene Therapy Using Orthogonal Techniques

Viruses are increasingly used as vectors for delivery of genetic material for gene therapy and vaccine applications. Recombinant adeno-associated viruses (rAAVs) are a class of viral vector that is being investigated intensively in the development of gene therapies. To develop efficient rAAV therapies produced through controlled and economical manufacturing processes, multiple challenges need to be addressed starting from viral capsid design through identification of optimal process and formulation conditions to comprehensive quality control. Addressing these challenges requires fit-for-purpose analytics for extensive characterization of rAAV samples including measurements of capsid or particle titer, percentage of full rAAV particles, particle size, aggregate formation, thermal stability, genome release, and capsid charge, all of which may impact critical quality attributes of the final product. Importantly, there is a need for rapid analytical solutions not relying on the use of dedicated reagents and costly reference standards. In this study, we evaluate the capabilities of dynamic light scattering, multiangle dynamic light scattering, and SEC–MALS for analyses of rAAV5 samples in a broad range of viral concentrations (titers) at different levels of genome loading, sample heterogeneity, and sample conditions. The study shows that DLS and MADLS® can be used to determine the size of full and empty rAAV5 (27 ± 0.3 and 33 ± 0.4 nm, respectively). A linear range for rAAV5 size and titer determination with MADLS was established to be 4.4 x 1011 – 8.7 x 1013 cp/mL for the nominally full rAAV5 samples and 3.4 x 1011 – 7 x 1013 cp/mL for the nominally empty rAAV5 samples with 3–8% and 10–37% CV for the full and empty rAAV5 samples, respectively. The structural stability and viral load release were also inferred from a combination of DLS, SEC–MALS, and DSC. The structural characteristics of the rAAV5 start to change from 40 oC onward, with increasing aggregation observed. With this study, we explored and demonstrated the applicability and value of orthogonal and complementary label-free technologies for enhanced serotype-independent characterization of key properties and stability profiles of rAAV5 samples.

Products:
Contract Research - Chemistry
Technology:
Multi-Angle Dynamic Light Scattering (MADLS)
Industry:
Biologics
Characterization of Recombinant Adeno-Associated Viruses (rAAVs) for Gene Therapy Using Orthogonal Techniques
Article

18 May 2020 | English

Global presentation: Concept Life Sciences

Concept Life Sciences are a people centric organisation working to solve complex human health challenges. We address these through continuous innovation, exceptional science and the highest customer service. We accelerate the customer’s discovery and development through applying our expertise to their challenges. The life sciences industry is fast moving with the acceptance of new technologies and innovative use of established tools to solve the complex questions for which our clients require solutions.

Products:
Contract Research - Analytical Services
Industry:
Pharmaceutical
Global presentation: Concept Life Sciences
Article

17 April 2020 | English

Applications of X-ray diffraction in heavy mineral processing

The use of high speed detectors turned X-ray diffraction (XRD) into an important tool for quality and process control in mining industries, especially in the sector of heavy mineral concentration and processing. Next to the information about the composition of a raw ore, heavy mineral concentrate or titania slag it provides useful information by the quantitative determination of the crystalline phases and the amorphous content. The analysis of the phases can help to optimize the concentration of ores and reduction of ilmenite concentrate. Traditionally quality control of heavy mineral concentrates and titania slag relies mainly on elemental, chemical, gravimetrical and magnetic analysis. Since the efficiency of concentration and reduction depends on the content of the different titanium and iron phases, such as ilmenite FeTiO3, rutile TiO2, anatase TiO2 or the various titanium oxides with different oxidation stages, a fast and direct analysis of the phases is required.The three case studies of this paper demonstrate how XRD and cluster analysis can be used for process optimization and quality control. The potential of XRD as an automatable, reliable tool, useful in the characterization of heavy mineral concentrates and titania slag will be demonstrated.

Technology:
X-ray Diffraction (XRD)
Industry:
Minerals
Applications of X-ray diffraction in heavy mineral processing
Article

13 April 2020 | English

Nanoparticle number concentration measurements by multi-angle dynamic light scattering

We present the use of Multi-angle Dynamic Light Scattering (MADLS®) for the measurement of nanoparticle concentration. We describe the theory of the method and its application to nanoparticles made of gold, silica and polystyrene, with diameters ranging from 30 to 400 nm, and demonstrate some of the limitations with particles of sizes 500 nm and above. We evaluate the method accuracy, linearity and reproducibility, as well as the operational nanoparticle concentration and size range. We show that the concentration working range depends on the material’s optical properties, size and concentration. Here it is shown that the level of accuracy that can be expected for the concentration of particles is typically within 50% of the nominal value across a range of materials and sizes and, for some samples, within 20%. The repeatability of the measurements, in terms of relative standard deviation, is typically below 30%. A linearity of within 40% across a concentration range of 3·108 to 2·1011 mL−1 for concentration measurements was also demonstrated by using gold nanoparticles and gravimetric dilutions for method validation. Overall, we show that MADLS® is a rapid and straightforward method for the reproducible measurement of particle concentration, as well as size, requiring minimal sample preparation, without the need to calibrate using a pre-determined concentration series, and applicable to a broad range of materials. These features make it an ideal tool to support both development and quality control of particle materials for a broad range of applications.

Products:
Zetasizer Ultra
Technology:
Multi-Angle Dynamic Light Scattering (MADLS)
Industry:
Pharmaceutical
Nanoparticle number concentration measurements by multi-angle dynamic light scattering
Article

01 April 2020 | English

Integrated discovery: Concept Life Sciences

Concept Life Sciences has grown and evolved through the acquisition of key industry CRO’s. Our strengths of specialism now provide integrated or focused stand-alone drug discovery and development services globally. We work together across our therapeutic areas and service specialties to give you a dedicated project team.

Products:
Contract Research - Analytical Services
Industry:
Pharmaceutical
Integrated discovery: Concept Life Sciences
Article

01 April 2020 | English

Integrated development services: Concept Life Sciences

Concept Life Sciences is a knowledge and science-led contract research organization. We are problem solvers and trusted partners with a proven track record in life sciences, laboratory based analytical testing and specialist consulting. We provide world leading integrated solutions focused around de-risking development of NCE’s, through chemistry and pharmaceutical development to biotechs, spinouts, medium and large pharma clients.

Products:
Contract Research - Analytical Services
Industry:
Pharmaceutical
Integrated development services: Concept Life Sciences