Here you can search and access all the content created by Malvern Panalytical scientists and engineers for the benefit of our customers. Below is a summary of the types of information available:

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Application notes describe the application of one or more of our analytical methods to resolve issues or answer questions.

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This eBook explores several ways in which Malvern Panalytical’s technologies and expertise can assist pharmaceutical scientists in their quest to develop high quality, safe and effective products, and accelerate their speed to market.

Products:
Mastersizer range
Date:
April 15 2020
Language:
English

Jar testing simulates the coagulation / flocculation process in a water treatment plant. In a set of beakers, a defined amount of raw plant water is mixed with varying amounts of coagulant. Each beaker receives an increasing incremental dose of coagulant and is then stirred for a set amount of time to mimic plant operation. The formation of floc during this test simulates plant operation. Observations from the floc formation indicate a preferred range of coagulant dosage. Thus, jar testing can help identify the parameters that promote an appropriate final water quality. While this jar test is simple to perform, it does require time, typically about 2-3 hours, including preparation and wait for settlement. Since water quality can change seasonally (summer algae growth, flood events, forest fires) the jar test has to be repeated regularly. A significantly faster method is the measurement of zeta potential expressed in milli Volt (mV). Here, the water is exposed to an electric and scientifically supported field, and the movement of colloidal particles indicates their net charge under the specific water conditions. We present details of the zeta potential method and compare results with jar testing. At the example of alum (Aluminium Sulfate, Al2(SO4)3) as coagulant, we show that the optimal dose is related to a favorable zeta potential range of -8mV to +3mV. ​ Not shown here, the use of ferric (Iron Chloride or Iron Sulfate) typically correlates with the same zeta potential range to optimize water treatment plant operation. Each coagulant chemistry has an optimal pH range where it is most effective, so it is also important to monitor pH in the plant and maintain the similar pH during the jar testing.

Products:
Zetasizer WT
Date:
March 23 2015
Language:
English

100 years ago Gustav Mie developed an analytical solution for Maxwell equations to describe light scattering by spherical particles. One of the most important industrial applications of his model is in laser diffraction particle size analysis.

Products:
Mastersizer range
Date:
January 8 2010
Language:
English

This white paper explores some of the reasons why laser diffraction has become one of the most widely used technologies for routine particle size analysis across a diverse range of industrial sectors.

Products:
Mastersizer range
Date:
March 25 2011
Language:
English

Setting meaningful and realistic product specifications is essential in the application of Quality by Design during pharmaceutical development. Here we consider the process of selecting specifications, using particle size as an example parameter.

Products:
Mastersizer 3000
Date:
March 25 2011
Language:
English

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