Knowledge Center

At Malvern Panalytical, we are immensely proud of our laser diffraction particle size analyzer, the Mastersizer 3000. Every day, we engage with scientists, researchers and quality control professionals who tell us how the Mastersizer 3000 has revolutionized the way they acquire particle size data to efficiently control processes and create exceptional products. One fundamental reason for ...

Despite the potential damaging impact of contaminants on the properties of AM parts, detecting undesired intruders in metallic powder feedstocks remains a challenging exercise. There is a consensus on the definition of contamination, but not yet a widely accepted strategy on how to detect it in a non-destructive and cost-effective way, directly on the powders (see ISO/ASTM 52907 [1]). Contamination ...

The interaction between compounds and their drug targets – particularly the binding kinetics – is an essential part of the identification and validation of new therapeutics and small-molecule drugs. But, despite the many technological advances in research and development, many challenges remain in using kinetic analysis for the early stages of drug discovery. In this whitepaper, we aim to ...

X-ray powder diffraction (XRPD) has long been a powerful tool in metallurgy, but its unsuitability for parts with large grain sizes has made its use for the analysis of metal additively manufactured parts a challenge. In this article, Dr. Scott Speakman, Malvern Panalytical, reports on a study in which specimens of soft magnetic Fe-Si steel were made by PBF-LB using a variety of raster and ...

Paints and coatings are highly complex multi-component systems that pose many challenges for the formulation chemist. Ongoing control of raw materials and final formulations is essential for ensuring product quality and customer satisfaction, while an in-depth understanding of physical properties is necessary to devise new formulations. This white paper discusses these challenges, and explains ...

Nickel laterite in the Sorowako and Petea area of South Sulawesi, Indonesia, is classified into one of two main types, depending on the bedrock and silica-to-magnesia ratio in the mineralization: West Block and East Block. The East Block mine is high-recovery, low-olivine (∼60­–65%)parent rock, whereas West Block is low-recovery, high-olivine (∼80–90%)parent rock. Petea is a mainly lateritic ...

Amid growing concern for our climate, industries in a wide range of markets are seeking to reduce their environmental impact. This includes the cement industry, where there is a growing drive to reduce energy consumption and drivemove toward more circular, net-zero production. At the same time, there is also a push to save costs and improve quality. Automated process control can deliver significant ...

DSC is a trusted and proven technique for protein thermal stability screening in vaccine development. Due to the wide operating temperatures, clear indication of the transition stage and straightforward operating conditions that do not compromise protein stability, DSC can achieve the highest standards of screening. By accurately determining the Tm and exact protein stability profile, DSC ...

Progressing drug development without fully understanding the structure and stability of polymorph variants can quickly lead to potential safety, efficacy or quality issues. Gaps in polymorph profiling can also lead to ambiguity in patent applications, which can have disastrous consequences even years into a drug product’s lifecycle. A clear understanding of an API and all its forms - through ...

DLS and ELS are versatile techniques that are used to characterize the size and zeta potential of particulate materials. They are most commonly applied to colloidal systems, nanoparticles and macromolecules in solution or dispersion. Of course, the specifications of a DLS/ELS instrument are vital when comparing systems from different manufacturers. But if you don’t use your system in the ...