NanoSight Pro

The software interface is logical and user friendly, even for a first time user.

Rebecca Dragovic — Teaching Fellow & Research Scientist, Nuffield Department of Women’s & Reproductive Health, University of Oxford

From our bench to yours - at a fraction of the cost

• Get access to top-tier lab instruments
• Expert maintenance by our experienced team
• Full support with installation and training*
• Same warranty as a new system
• Fast shipping

Reserve your demo unit

^{*Terms and conditions apply}

It is the easiest bit of equipment I have ever installed in the lab

Oliver Huseyin — Research scientist, MIP Diagnostics Limited

Smart Manager

Unleash the potential of your data

Until now, instrument data has too often been stuck in manual records, spreadsheets or site-specific servers. By connecting your NanoSight Pro to our Smart Manager and continually analyzing instrument data in the cloud, you can unleash its full potential. This is just one of our digital solutions that are part of Malvern Panalytical's Smart Manager.

The Malvern Panalytical NanoSight Pro can be used in many key applications, including:

Extracellular Vesicles (EV)

Whilst the research into the generation and functions of extracellular vesicles is still evolving, it is important to monitor and control their isolation and purification. NanoSight NTA provides quick and easy characterization of both the size and concentration of vesicles in aqueous buffers, giving confidence in the quality of the sample used in any downstream experiments, whilst the use of fluorescence can assist in elucidating the origin subpopulations of EVs.

Whitepaper: NTA Exosomes and Microvesicles

Read more: Extracellular Vesicles

Virus and Vaccines

Manufacture of vaccines requires controlled production processes to ensure that the materials can be appropriately dosed and recognized by the immune system. NTA assists in the optimization of manufacturing processes by ensuring the size distribution of the vaccine is maintained. As NTA is also able to count and size viruses, it can be used as a faster alternative to titer assays.

Application Note: Total virus titer in minutes

Drug Delivery & Gene Therapy

With drug delivery and gene therapy products, 70-150 nm is the typical size of particles required to ensure effective disease targeting in the clinical. NTA is ideally suited to study the size of these particles from early stage research through to candidate screening, formulation development and clinical batch monitoring whilst the concentration measurement allows for dose determination of the final product as well as for use in in vitro and in vivo assays.

Whitepaper: NTA Applications in drug delivery

Biotherapeutics

Temperature, pH change, agitation, shear and time all impact the stability of biotherapeutic proteins, causing denaturation and aggregation which can cause loss of efficacy and the potential for an unwanted immune response. NTA provides high resolution size distributions of sub-visible aggregates in a formulation for safety and quality assurance.

Application note: High resolution sizing and concentration measurements of sub-visible protein aggregates using NTA

Nanomaterials/colloids/toxicology

As nanomaterials are incorporated in to everyday items, they are coming to the attention of regulatory bodies. There is a requirement to fully characterize these particles, their properties and contribution in the final product. NanoSight can provide a number-based concentration for these nanomaterials and high-resolution size distributions for those working at the nanoscale in industrial, environmental and toxicological fields.

Application note: Characterization of nanoparticle size and state in nanotoxicological and ecotoxicological studies using Nanoparticle Tracking Analysis (NTA)

Ultrafine bubbles

In recent years work on ultrafine bubbles has been gathering momentum for use in industrial cleaning and water treatment, agriculture and food, and medical applications amongst others. Their relatively low concentration and small size are a challenge for many traditional nanoparticle characterization techniques whereas NTA is particularly adept at the detection and analysis of these bubbles.

Webinar: Nanobubbles: What are they, what are their uses and how can I measure them?

General

Technology	Nanoparticle Tracking Analysis
Size range (diameter)1	10 nm - 1000 nm
Particle concentration2	106 to 109 particles / mL
Minimum sample volume	250 μL
Advanced Concentration Algorithm	Concentration Upgrade

System

Product Compliance	Product Laser Class 1 (BS EN 60825-1:2014) EMC Directive (EN IEC61326-1:2021) Low Voltage Directive (IEC 61010-1:2010 IEC 61010-1:2010/AMD 1:2016)
Camera	High sensitivity sCMOS (USB-3)
Laser information	Beam wavelength (maximum power output): 405 nm, max power <70 mW 488 nm, max power <55 mW (blue) 532 nm, max power <60 mW (green) 642 nm, max power <50 mW (red)
Temperature control range	5 °C below ambient up to 70 °C
Temperature readout	Automatic
Syringe pump	Continuous sample flow with 1 mL syringes
Dimensions (W, D, H)	250 x 350 x 340 mm
Weight of instrument	11 kg
Weight of laser module	1.6 kg
Power requirements	AC 110 – 240 V, 50-60 Hz, 4.0A
Ambient operating conditions	Up to 80% rH at 31 °C then decreasing linearly to 50% at 40 °C

Additional options

Fluorescence – automatic selection3	For up to 5 filters

¹ Dependent on sample and instrument configuration
² Sample dependent
³ Optional functionality. Long-pass filters available for each laser wavelength

Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.

When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.

Help Desk

• Telephone and email support .
• Operators who take responsibility for your call and ensure your query is answered.

Training

• User training events

Software downloads

• A simple mechanism for receiving updates and new features

Malvern Panalytical's service options- choose the right plan for you:

Malvern Panalytical Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

Malvern Panalytical Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

Malvern Panalytical Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

*including labour & travel costs  ***available at an additional cost