Vaccine development

Innovation in vaccine development and production is moving at speed. However, developing novel vaccines is uniquely challenging.  

Do you recognize these challenges?  

• Staying ahead of the competition, especially when 3rd generation vaccines receive ever-higher levels of investment
• Implementing appropriate methods and analytical tools to create consistent, safe and efficacious vaccine products 
• Staying compliant with constantly evolving, ceaselessly changing regulatory guidelines
• Finding the efficiencies, people, and resources to develop innovative products and processes 
• Successfully transferring new discoveries to scale-up and manufacturing
• Keeping up to date with the latest technology and approaches 

Whatever approach you are taking to vaccine development, we can help you implement the characterization tools and know-how you need to bring your life-changing vaccines to the world. 

From material characterization to vaccine manufacturing and quality control – we can help you overcome your challenges: 

• Our experienced scientists can act as a flexible extension to your team – if you’re facing a challenge with your program then chances are, our team has faced it before
• Once we’ve identified the right methods, we provide development services to overcome your specific challenges in the most efficient way
• Our approach bridges the physicochemical characterization, expertise, bandwidth or technology gaps in your organization. 
• Our physicochemical characterization solutions have applications across numerous stages of vaccine development, from fundamental research to manufacturing and production 
• We help you develop reliable, repeatable techniques that improve the efficiency of your workflows (without you having to break a sweat)
• Access training and support to upskill your team and quickly realize the full value of your investment in the analytical technology

Are you ready to combine next-level analytical tools with decades-long experience to help drive forward the next wave of vaccine products? 

Discover new insights: Vector analytics webinars

Want to know more? Take a look at our tools and resources to support your vaccine development:

Differential Scanning Calorimetry (DSC) on the MicroCal PEAQ-DSC enables understanding and monitoring of the higher-order structure (HOS) and thermal stability of proteins at every stage of virus-based vaccine development, and during process development for recombinant products. DSC is also used to understand the thermal stability of liposomes used as carriers in nucleic acid-based vaccines.

Differential scanning fluorimetry (DSF) on the Zetasizer Core complements DSC by providing high-throughput thermal stability screening. DSF tracks changes in a protein's intrinsic fluorescence during a controlled temperature ramp to determine melting temperature (T_m) and map conformational stability – without dyes, labels, or additional reagents.

Used alongside DSC, DSF enables rapid early-stage triage of vaccine candidates and formulation conditions, reserving deeper DSC analysis for the most promising leads.

Dynamic Light Scattering and laser diffraction have wide-ranging application for the measurement of particle size and size distribution, to detect the presence of aggregates and ensure sample homogeneity in the development of vaccines of all types.

Depending on the particle size involved, Multi-Angle Dynamic Light Scattering and Nanoparticle Tracking Analysis are used to measure viral titer throughout the development lifecycle for virus-based vaccines.

Electrophoretic light scattering (ELS) on the Zetasizer Advance range is used in the characterization and formulation development of products such as mRNA vaccines that use virus-like particles (VLPs), liposomes, and other nanoparticles as carriers to determine size and colloidal stability.

Dynamic Light Scattering (DLS) and Static Light Scattering (SLS) on the Zetasizer Core extend this capability into a high-throughput, plate-based workflow, enabling colloidal stability screening across multiple candidates and formulation conditions simultaneously. Nanoparticle Tracking Analysis (NTA) on the NanoSight Pro adds particle-by-particle size and concentration data for heterogeneous populations that ensemble DLS cannot fully resolve. These include sub-micron aggregated species associated with immunogenicity risk.

Particle concentration is critical when using carriers such as VLPs, liposomes and other nanoparticles. Nanoparticle Tracking Analysis and Multi-Angle Dynamic Light Scattering are used to measure particle concentration during characterization and formulation development stages. 

Differential Scanning Calorimetry on the MicroCal PEAQ-DSC range is a fundamental tool for characterizing proteins and plays a key role in the understanding of protein stability under various conditions. Dynamic light scattering on the Zetasizer Advance range is used to investigate and predict protein stability and to provide stability-indicating data that is used throughout development.

The Zetasizer Core extends this even further, enabling simultaneous DLS, SLS, and DSF measurements across large candidate sets – supporting faster candidate selection and formulation screening at earlier stages of development.

Whatever characterization challenges you are facing, chances are we’ve worked with a team just like yours and helped them implement the technology and methods needed to make safe and effective vaccines. 

To find out how our team of experts can help you overcome your challenges, contact us today.