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NanoSight Pro

Characterizing Nano- and Biomaterials has never been so quick, easy, and accurate.

With the introduction of the NanoSight Pro, Malvern Panalytical provides the best in class, simple and rapid NTA solution for nano- and biomaterials characterization.

The combination of advanced engineering and a blend of smart features assures NTA measurements are efficient, quick, and accessible to all users. Powered by machine learning, NS Xplorer software enables automated measurements, removes subjectivity, and provides the highest quality size and concentration data for both, the light scatter and fluorescence analysis. 

Interchangeable lasers allow application flexibility, whilst Smart Manager connection assures robustness without a worry for quality issues or downtime. 

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Overview

The software interface is logical and user friendly, even for a first time user.

Rebecca Dragovic — Teaching Fellow & Research Scientist, Nuffield Department of Women’s & Reproductive Health, University of Oxford


Features and benefits

Quick install & analysis

NanoSight Pro can be used by every user in every lab. Smart installation allows you to get up and running quickly. With minimum setup, easy operation and intuitive NS Xplorer software you can measure your samples in minutes.

Quick install & analysis

Intelligent & automated

Powered by machine learning and intelligent features, NanoSight Pro automates processing and eliminates human error, delivering superior particle identification and precise particle tracking for the highest quality and reproducible data.

Intelligent & automated

Highest resolution

The NanoSight Pro measures nanoscale particles in the range of 10 nm - 1000 nm including low scattering and biological particles. Particle–by–particle analysis assures high resolution size and concentration data with visual confirmation.

Highest resolution

Power of fluorescence

In addition to light scatter, fluorescence signals can be detected from fluorescently tagged biologics or synthetic particles providing even greater insight into your sample. Interchangeable laser modules with the choice of four excitation wavelengths can be used along with the matching long pass filters for the optimum setup supported by analysis in flow for better sampling and tracking of even photobleaching samples. 

The greater fluorescence sensitivity enables subpopulation identification including surface markers, internal cargo detection or depreciation of contaminants sensitivity.

Power of fluorescence

What customers think

It is the easiest bit of equipment I have ever installed in the lab

Oliver Huseyin — Research scientist, MIP Diagnostics Limited

Connected world

Smart Manager

Unleash the potential of your data

Until now, instrument data has too often been stuck in manual records, spreadsheets or site-specific servers. By connecting your NanoSight Pro to our Smart Manager and continually analyzing instrument data in the cloud, you can unleash its full potential. This is just one of our digital solutions that are part of Malvern Panalytical's Smart Manager.

Key applications

The Malvern Panalytical NanoSight Pro can be used in many key applications, including:

Extracellular Vesicles (EV)

Whilst the research into the generation and functions of extracellular vesicles is still evolving, it is important to monitor and control their isolation and purification. NanoSight NTA provides quick and easy characterization of both the size and concentration of vesicles in aqueous buffers, giving confidence in the quality of the sample used in any downstream experiments, whilst the use of fluorescence can assist in elucidating the origin subpopulations of EVs.

Whitepaper: NTA Exosomes and Microvesicles

Virus and Vaccines

Manufacture of vaccines requires controlled production processes to ensure that the materials can be appropriately dosed and recognized by the immune system. NTA assists in the optimization of manufacturing processes by ensuring the size distribution of the vaccine is maintained. As NTA is also able to count and size viruses, it can be used as a faster alternative to titer assays.

Application Note: Total virus titer in minutes

Drug Delivery & Gene Therapy

With drug delivery and gene therapy products, 70-150 nm is the typical size of particles required to ensure effective disease targeting in the clinical. NTA is ideally suited to study the size of these particles from early stage research through to candidate screening, formulation development and clinical batch monitoring whilst the concentration measurement allows for dose determination of the final product as well as for use in in vitro and in vivo assays.

Whitepaper: NTA Applications in drug delivery

Biotherapeutics

Temperature, pH change, agitation, shear and time all impact the stability of biotherapeutic proteins, causing denaturation and aggregation which can cause loss of efficacy and the potential for an unwanted immune response. NTA provides high resolution size distributions of sub-visible aggregates in a formulation for safety and quality assurance.

Application note: High resolution sizing and concentration measurements of sub-visible protein aggregates using NTA

Nanomaterials/colloids/toxicology

As nanomaterials are incorporated in to everyday items, they are coming to the attention of regulatory bodies. There is a requirement to fully characterize these particles, their properties and contribution in the final product. NanoSight can provide a number-based concentration for these nanomaterials and high-resolution size distributions for those working at the nanoscale in industrial, environmental and toxicological fields.

Application note: Characterization of nanoparticle size and state in nanotoxicological and ecotoxicological studies using Nanoparticle Tracking Analysis (NTA)

Ultrafine bubbles

In recent years work on ultrafine bubbles has been gathering momentum for use in industrial cleaning and water treatment, agriculture and food, and medical applications amongst others. Their relatively low concentration and small size are a challenge for many traditional nanoparticle characterization techniques whereas NTA is particularly adept at the detection and analysis of these bubbles.

Webinar: Nanobubbles: What are they, what are their uses and how can I measure them?

Specification

General

Technology Nanoparticle Tracking Analysis
Size range (diameter)1 10 nm - 1000 nm
Particle concentration2 106 to 109 particles / mL
Minimum sample volume 250 μL
Advanced Concentration Algorithm Concentration Upgrade

System

Product Compliance Product Laser Class 1 (BS EN 60825-1:2014)
EMC Directive (EN IEC61326-1:2021)
Low Voltage Directive (IEC 61010-1:2010
IEC 61010-1:2010/AMD 1:2016)
Camera High sensitivity sCMOS (USB-3)
Laser information Beam wavelength (maximum power output):
405 nm, max power <70 mW
488 nm, max power <55 mW (blue)
532 nm, max power <60 mW (green)
642 nm, max power <50 mW (red)
Temperature control range 5 °C below ambient up to 70 °C
Temperature readout Automatic
Syringe pump Continuous sample flow with 1 mL syringes
Dimensions (W, D, H) 250 x 350 x 340 mm
Weight of instrument 11 kg
Weight of laser module 1.6 kg
Power requirements AC 110 – 240 V, 50-60 Hz, 4.0A
Ambient operating conditions Up to 80% rH at 31 °C then decreasing linearly to 50% at 40 °C

Additional options

Fluorescence – automatic selection3 For up to 5 filters

1 Dependent on sample and instrument configuration
2 Sample dependent
3 Optional functionality. Long-pass filters available for each laser wavelength

Support

Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.

When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.

Help Desk

Training

  • User training events

Software downloads

Malvern Panalytical's service options- choose the right plan for you:

Malvern Panalytical Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

Malvern Panalytical Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

Malvern Panalytical Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum Plan Gold Plan Bronze Visit
Annual PM/PV Test
yes
yes
no
Telephone / Email Support
yes
yes
no
Priority Response
yes
yes
no
Emergency Breakdown visits*
yes
yes
no
Parts Included
yes
no
no
Technical & Software Support
yes
yes
yes
IQ/OQ (Pharma)***
yes
yes
yes

*including labour & travel costs  ***available at an additional cost