Zetasizer Core

Next generation biophysical screening at scale

Accelerate discovery and development with the first system to combine DLS, SLS and DSF into a single microwell plate workflow.

Meet Zetasizer Core.

  • Combines DLS, SLS, and DSF in a single workflow, with a dedicated SLS optical path for precise quantification of protein self-association and repulsion (A₂/B₂₂).

  • Built on advanced thermal control, Zetasizer advance algorithms, and precision optical design.

  • Screen structural stability across 192 samples at 1 °C/min temperature ramps.

  • Full compatibility with standard microwell plates – zero proprietary lock-in or high consumable costs.

Replace uncertainty with reproducible insight

Meet the first high-throughput microwell plate reader with built-in Dynamic Light Scattering (DLS), Static Light Scattering (SLS), and Intrinsic Differential Scanning Fluorimetry (DSF).

When candidate selection depends on accuracy, clarity, and throughput, the Zetasizer Core delivers. A single run generates a large amount of structurally precise data, so you can advance your pipeline with confidence.

Features that deliver results

  • Exceptional data quality at scale: Industry-leading precision for confident, high-throughput decision-making

  • Multi-parameter stability insights: Simultaneous measurement of size, colloidal stability, and structural stability

  • Advanced thermal control: Precise knowledge of the plate’s thermal profile ensures absolute data reproducibility

  • Standard plate compatibility: Seamless integration with 96-, 384-, and 1536-microwell plates

  • Dedicated SLS Detector: Transforms B22 / second virial coefficient analysis from an expert-only measurement into a routine screening tool.

  • Impeccable heritage: High-throughput DLS powered by the same trusted algorithms and adaptive correlation technology as the market-leading Zetasizer Advance

  • Automation-ready: Designed for effortless integration into automated robotic workflows

  • ZS Discover software: Intuitive interface lets users of all levels go from sample setup to results in just 5 clicks

Smart software for simplicity

Zetasizer Core’s ZS Discover software is purpose-built for high-throughput biologics stability screening - powerful enough for experts but intuitive enough for beginners. ZS Discover software allows any user to go from sample setup to results in only five clicks – with guided workflows, automatic multi-transition fitting, and built-in analysis tools that remove subjectivity from data interpretation.

Software

Tailored to your application

Discover how the Zetasizer Core helps accelerate stability characterization across a wide range of molecules and biopharmaceutical workflows.

Key applications

Proteins

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Antibodies

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Lipid Nanoparticles

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Industry applications

Pharmaceutical

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Academia

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CRO / CDMO

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Compliance made easy with OmniTrust

Coming in Q1 2027: Ensure system access and records are secure, consistent, and easy to review for 21 CFR Part 11 with OmniTrust - our compliance solution for regulated environments.

Regulated environment

From sample to insight, faster

5 steps to high-resolution, reproducible data across key stability parameters

The Zetasizer Core supports a streamlined workflow from plate setup to data output. By reducing manual handling, enabling standardized plate formats, and consolidating multiple measurements into one system, it helps scientists spend less time moving between instruments and more time making decisions.

Which Zetasizer Core is right for you?

Our two Zetasizer Core models both deliver high-throughput size and colloidal stability analysis. For monitoring particle size, aggregation, and physical shelf-life alone, the Zetasizer Core, with SLS and DLS technology, is a high-throughput workhorse. For total stability analysis, the flagship Zetasizer Core DSF combines DLS, SLS, and DSF.

Zetasizer Core DSF


Combines the colloidal insights of DLS and SLS with the powerful structural data of DSF. Performs sizing and aggregate measurements across automated thermal ramps, mapping physical particle changes directly to structural unfolding events.

Best for: Protein pre-formulation screening, early-stage candidate selection, structural biology R&D, and high-throughput profiling where tracking thermal denaturation (Tm) is critical to long-term product stability.

Zetasizer Core


For labs focused strictly on physical stability, colloidal stability screening, and routine quality checks. Delivers high-throughput DLS and SLS performance. 



Best for: Routine formulation testing, quality control, scale-up monitoring, and robust colloidal screening workflows where thermal unfolding data is not required.

How our products compare

Zetasizer Core DSF Zetasizer Core
High-throughput structual and colloidal stability screening for total pipeline security when working with proteins, antibodies, or delicate biomolecules. High-throughput size and colloidal characterization for monitoring particle size, aggregation, and physical shelf-life.

Measurement type

  • Sizing and aggregation (dH, PI)
  • Colloidal stability (kD, B22)
  • Thermal unfolding (Tm, Tonset)
  • Aggregation mapped to structural unfolding (Tagg)
  • Ligand binding (EC50)
  • Chemical denatuaration (Cm)

Measurement type

  • Sizing and aggregation (dH, PI)
  • Colloidal stability (kD, B22)

Technology

  • DLS
  • SLS
  • DSF

Technology

  • DLS
  • SLS

Sample throughput

Measure up to 192 samples per minute

Sample throughput

Measure up to 192 samples per minute

Request a Quote

Request a Quote

Built on Zetasizer expertise

The Zetasizer Core builds on decades of MP experience in light scattering and protein characterization. It extends trusted Zetasizer technology into a high-throughput, plate-based workflow designed for biologics discovery, formulation, and development.

Why you can trust us:

  • 35+ years of Zetasizer DLS expertise
  • Trusted algorithms for reliable light-scattering analysis
  • Method continuity for existing Zetasizer users
  • Designed to support standardization across laboratories
  • Developed for high-quality data at scale
  • 21 CFR Part 11 functionality coming soon

Resources

Access expert insights, application notes, and technical resources to help you get the most from your stability characterization workflows.

Specification

Minimum sample volume 4 uL (1536-well plate)
Minimum sample concentration 14 kDa, 0.125 mg/mL
Range Average dH, 0.6 nm – 2000 nm
Minimum acquisition time 1 sec
Fitting method Malvern Panalytical Zetasizer cumulants and multimodal regularization
Advanced acquisition method Malvern Panalytical Zetasizer Adaptive Correlation

Ready for complete stability on one platform?

Experience next-generation biophysical stability at scale. Zetasizer Core helps your team accelerate biologics development, improve confidence in stability decisions, and scale your analytical workflows.

  • Zero proprietary consumables: needs standard microwell plates only
  • 4 µL minimum sample volume (1536-well)
  • 5 clicks from setup to results
  • Measure up to 192 samples per minute
  • 35+ years of trusted Zetasizer DLS expertise