Not sure which Zetasizer system is right for your requirements?. Find your perfect Zetasizer

Find your perfect Zetasizer

Zetasizer Lab

Classic side scatter particle size and zeta potential analyzer with enhanced capabilities

Our Zetasizer Lab system offers traditional 90-degree side-scatter size measurements but still offers enhanced features. The Zetasizer Lab incorporates Adaptive Correlation, M3-PALS and constant current zeta mode as well as our extended size range analysis when used with ZSU1002 capillary cell. The Zetasizer Lab also ships with ZS Xplorer, our easy-to-use analytical software. ZS Xplorer offers instant feedback on data quality, and guidance on how to improve your results.

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Features and benefits

 Works with OmniTrust: Malvern Panalytical's compliance solution for the regulated environment

The Zetasizer Lab is the perfect entry-level system, offering a wide range of features, including:

  • DLS analysis: particle size measurements from 0.3 nm to 10 μm
  • Extended size range analysis offers improved accuracy for particle sizes above 1 μm, and indicative results above 10 μm (using ZSU1002 Low Volume Disposable Sizing Cell)
  • Zeta potential of nanoparticles and colloids using M3-PALS analysis and constant current zeta mode
  • Molecular weight using Static Light Scattering at 90°
  • Supports use of Low Volume Disposable Capillary Cell for size measurements in sample volumes as low as 3 μL
  • Available in Blue Label and Red Label variants:
    • Choose Blue Label for routine sample investigation such as metallic colloids, metal oxides and pigments
    • Choose Red Label for more challenging sample types, such as proteins, surfactant solutions and low solid content samples
  • On-site upgradeability to either Zetasizer Pro or Zetasizer Ultra models

Which Zetasizer is right for me?

Zetasizer UltraZetasizer ProZetasizer Lab
Size Measurement PrincipleNon-Invasive Back Scatter (NIBS)
Dynamic Light Scattering
Dynamic Light Scattering (90° and 13°)
Multi-Angle Dynamic Light Scattering (MADLS®)
Non-Invasive Back Scatter (NIBS)
Dynamic Light Scattering
Classical 90° Dynamic Light Scattering
Zeta Measurement PrincipleELS with M3-PALS and Constant Current Zeta ModeELS with M3-PALS and Constant Current Zeta ModeELS with M3-PALS and Constant Current Zeta Mode
Molecular Weight and B22 [1]Static Light Scattering (90° and 173°)Static Light Scattering (173°)Static Light Scattering (90°)
Optical Filter Wheel (Fluorescence/DDLS)YesYesNo
Low Volume Disposable Sizing Cell with Extended Size Analysis SupportYesNoYes
MADLS® (High Resolution DLS)YesNoNo
MADLS® - Particle Concentration/TiterYes2NoNo
21 CFR Part 11 compliant software3OptionalOptionalOptional
Range40.3 nm to 10 μm0.3 nm to 10 μm0.3 nm to 10 μm
Minimum Volume3 μL12 μL3 μL
Zeta potential
Size Range3.8 nm to 100 μm3.8 nm to 100 μm3.8 nm to 100 μm
Minimum Volume520 μL20 μL20 μL

1 Hardware capable; Software support coming soon
2 Red Label only
3 21 CFR Part 11 software features coming soon
4 10 um by default. Option to extend for Zetasizer Lab and Zetasizer Ultra coming soon
5 Patented Diffusion Barrier method in capillary cell

Key applications

The Zetasizer Advance Range is suitable for a wide range of applications, including:

Colloidal Silica
Sizing of colloidal silica is a critical requirement. This is easily and reproducibly measured using the Zetasizer Lab Blue Label.
Titanium Dioxide
Titanium dioxide use is wide-ranging. When used in paints or inks, agglomerate or aggregate formation can diminish product performance. The Zetasizer Pro Blue Label, used alongside the MPT‑3 Autotitrator, characterizes the impact of salt concentration on the stability of TiO2 and identifies the most stable pH region.

The strength of ceramics is linked to particle size, and the Zetasizer Ultra Blue Label is ideally placed to measure this. Al2O3 samples are often made of differently-sized particles which can easily be identified using MADLS. In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single angle DLS measurement.


For protein researchers, early access to characterization data can be a challenge, due to low sample volumes. This is easily overcome using the Zetasizer Lab Red Label with the capillary cell to confirm that samples meet quality requirements and that production and purification processes are optimized.

Carbon Dots (C-dots)
Photoluminescent C-dots are considered safer alternatives to quantum dots. Measuring fluorescent samples by DLS can be challenging due to additional photons emitted by the fluorophore. Available with NIBS on Zetasizer Pro Red Label, a filter removes this interference to provide accurate and reliable data.
Adeno-Associated Virus (AAV)
Monitoring viral concentration is important during development and production optimization. By using the Multi-Angle DLS (MADLS) based particle concentration measurement in the Zetasizer Ultra Red Label, both the size distribution and titer of the virus can be measured within a few minutes.

The Zetasizer Advance Range is used in many industries, including:

The Zetasizer Lab is an essential analytical tool for many academic laboratories worldwide, finding use in all applications where particle or molecular size and zeta potential analysis is required. The breadth of applications covered by Zetasizer systems, coupled with tens of thousands of scientific citations, have earned these instruments a central space in many scientific faculties.
Variations in molecule concentration, external temperature, level of agitation and time all impact the stability of biological molecules.  Instabilities mainly result in denaturation and aggregation of the molecule through which they can lose their biological function , elicit an immune response and consequently limit its therapeutic viability. Factors affecting therapeutic efficacy and immunogenicity therefore need to be monitored throughout the development pipeline especially at early stages to de-risk the biological drug molecule and limit late-stage failures. The Zetasizer range provides high quality, stability indicating data for biological drug molecules in a short time frame, enabling this measurement to be implemented throughout the development pipeline.   
Food and drink

Zetasizer systems are used to analyze particle size and zeta potential to improve the appearance and taste of foods, drinks and flavorings, and optimize dispersion and emulsion stability to extend product shelf life and improve product performance.


Zetasizer measurements of nanoparticle size distribution, dispersion properties, stability and propensity to aggregate are crucial to the design of new nanomaterials. The very large surface area of such materials may result in novel physical and chemical properties, such as increased catalytic activity, improved solubility or unexpected optical or toxicological behavior.

Paints, inks and coatings
Paint, ink and coating formulations must be stable to keep them in an optimum state over time without change or aggregation. Particle size and zeta potential, measured by the Zetasizer instruments, play important roles in determining a product’s properties, such as dispersibility, color, strength, finish, durability and shelf life.
The correct particle size and zeta potential can help ensure the production of effective therapeutics, delivered safely. Zetasizer systems are used to characterize the stability and quality of dispersions, emulsions and creams, reducing formulation time and speeding new products to market.


Specification for the Zetasizer Lab Red Label and Blue Label

Particle size and molecular size

Measurement principle
Classical 90° Dynamic Light Scattering
Measurement angle
90°, 13° (1)
Measurement range
0.3 nm to 15 μm (2)
Minimum sample volume 3 μL
Concentration range
Minimum Sample Concentration:
Blue Label: 1 mg/mL 15 kDa Protein
Red Label: 0.3 mg/mL 15 kDa Protein
Maximum sample Concentration: (3)
40% w/v

Zeta potential

Measurement principle
Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
Size range
3.8 nm – 100 μm
Minimum sample volume
20 μL (4)
Concentration range
Red Label: 1 mg/mL (5) to 40% w/v (6)
Blue Label: 10 mg/mL (5) to 40% w/v (6)
Sample conductivity range
Maximum: 260 mS/cm

Static Light Scattering (molecular weight)

Measurement principle
Static Light Scattering with Debye Plot
Molecular weight range
Lab – Red Model: 300 Da - 20 MDa 
Lab – Blue Model: 980 Da - 20 MDa 
+/- 10% typical


Avalanche Photodiode
Laser safety
He-Ne (633 nm)
Blue label: 4 mW Max 
Red label: 10 mW Max
Temperature control range
0°C to 120°C (7)
Dimensions (W, D, H) 322 mm x 565 mm x 245 mm
19 kg
AC 100-240 V, 50-60 Hz, 4.0 A
Power consumption
Max 100 W, Typical 45 W
Ambient conditions
+10°C to +35°C, 35 to 80% RH (Non-condensing)
USB 2.0 or higher


1 - Water as dispersant
2 - Indicative data available for particle sizes greater than 10 μm when using Extended Size Range analysis and low volume disposable sizing cell accessory
3 - Sample dependent
4 - Using patented diffusion barrier technique
5 - Measured using 15 kDa protein
6 - Measured using bile acid
7 - Dry nitrogen cell purge required for temperatures below dewpoint 
8 - Accuracy 0.1°C at 25°C, 0.2°C at 0°C, 0.5°C at 90°C


Configure the Zetasizer Lab for your applications and requirements with our range of configuration options:

MPT-3 Autotitrator

Automate your pH titrations

The MPT-3 is a cost-effective accessory for the Zetasizer Advance range, designed to automate your Zeta and/or Size vs. pH titrations, helping you understand how your materials behave as a function of pH.    

The zeta potential and/or size of your materials with pH changes can be critical in understanding: 

  • Material stability
  • Agglomeration
  • Flocculation 
  • Point of net-zero charge (isoelectric point)
  • Storage conditions

SV-10 viscometer

Viscosity measurement with speed, simplicity and accuracy.

The SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.

Cell and cuvette options

Disposable folded capillary cell (DTS1070)

Eliminate sample cross contamination between zeta potential measurements using a completely disposable cell.

The zeta potential of colloids and molecules is extremely sensitive to contamination from components of a previous sample used in a measurement cell. The use of a disposable cell completely eliminates this potential contamination issue.

The folded capillary cell provides the benefits of the accuracy of measurement of a capillary cell with the ease of use of a disposable cell.

Although, disposable, including the electrodes, for low conductivity samples each cell can be used for hundreds of measurements if required.

The cell can be used with the autotitrator, where multiple measurements are routinely done over a wide pH range.

Universal 'dip' cell kit

Reusable solvent resistant cell.

The dip cell is used for the measurement of zeta potential of samples in aqueous and non-aqueous dispersants, and is designed to be cleaned and reused. It is for batch measurements using standard polystyrene or glass cuvettes.

Low-volume disposable sizing cell kit (ZSU1002)

Our low volume disposable sizing cell (ZSU1002) design is unique in offering easy-fill, ultra-low volume size measurement in as little as 3 μL. 

  • Measure larger particles (up to 10 μm) with greater accuracy thanks to the inherent physical qualities of the capillary sizing cell
  • The cell also eliminates the errors associated with multiple scattering, allowing samples to be measured over a wider dynamic concentration range than would normally be possible at side scatter (90°)
  • The use of ZSU1002 is supported on Zetasizer Lab and Zetasizer Ultra models

High concentration zeta potential cell kit

Save time and effort by measuring zeta potential with little or no dilution.

The high concentration cell enables the measurement of the zeta potential of samples with little or no dilution in any Zetasizer Advance system that measures zeta potential.

The cell has a flow configuration so can be used for stop-flow size and zeta potential measurements using an MPT-3 autotitrator as well as batch measurements.

12mm Glass cell (PCS1115)

Glass cuvette for use with the dip cell.

  • For size and zeta potential measurements using the ‘dip’ cell
  • Compatible with aqueous and non-aqueous solvents and dispersants

12mm Square Polystyrene Cuvettes (DTS0012)

Disposable polystyrene cuvettes.

  • 100 disposable cells complete with 100 stoppers to avoid cross-contamination
  • For size measurements using aqueous dispersants
  • Compatible with zeta potential measurements using the dip cell

12mm square glass cell (PCS8501)

Glass cuvette for batch measurements.

  • For size and molecular weight measurements
  • Compatible with aqueous and non-aqueous solvents and dispersants

Low-volume quartz batch cuvette (ZEN2112)

Low-volume quartz batch cuvette for size and molecular weight measurements.

  • Compatible with size and molecular weight measurements with aqueous and non-aqueous solvents and dispersants
  • Minimum sample volume 12 microliters
  • Maximum volume 45 microliters


Protect your investment and ensure optimized performance at all times with Malvern Panalytical’s service plans.

When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.

Help Desk


  • User training events
  • E-learning

Software downloads

Malvern Panalytical’s service options- choose the right plan for you:

Malvern Panalytical Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

Malvern Panalytical Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

Malvern Panalytical Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
Telephone / Email Support
Priority Response
Emergency Breakdown visits*
Parts Included
Technical & Software Support
IQ/OQ (Pharma)***

*including labour & travel costs** Platinum 2 places per contract term, Gold 1 place per contract term***available at an additional cost

Connected world

Smart Manager

Unleash the potential of your data

Until now, instrument data has too often been stuck in manual records, spreadsheets or site-specific servers. By connecting your Zetasizer Lab to our Smart Manager and continually analyzing instrument data in the cloud, you can unleash its full potential. This is just one of our digital solutions that are part of Malvern Panalytical's Smart Manager.

Smart Install

Get your new Zetasizer Lab up and running faster when you choose to smart install. 

With comprehensive resources to help you quickly and safely set-up and verify the performance of your new instrument, there’s no need to wait for an engineer to do it for you. What’s more, smart install presents a new training opportunity as you receive full access to exclusive training material. 

How does it work?

When you follow the step-by-step video instructions, you could be up and running within 90 minutes of delivery of your new Zetasizer Lab. 

You don't need any specific skills or knowledge to perform a smart installation. Simply follow the instructions provided. 

Everything needed to get started is provided with your new instrument – all you need is an internet connection to access the online training. 

Exclusive e-learning content

Resources to get you up and running quickly and with confidence include:  

  • detailed video guides walk you through installation and set-up;
  • 15-months  access to the Essentials e-learning course, which is provided at no extra cost;
  • a comprehensive user manual.

Find out more about smart install.

Entry-level DLS with advanced functionality.

Entry-level DLS with advanced functionality.

Adaptive Correlation, M3-PALS and constant current zeta mode, with easy to use software and data quality feedback. All incorporated into a compact, user-friendly instrument.

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