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Dynamic Light Scattering (DLS)

Dynamic Light Scattering for size characterization of proteins, nanoparticles, polymers and colloidal dispersions

Dynamic light scattering (DLS), sometimes referred to as Quasi Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology, lower than 1nm.

Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.


Dynamic Light Scattering technology from Malvern Panalytical offers the following advantages:

  • Accurate, reliable and repeatable particle size analysis in one or two minutes.
  • Multi-Angle Dynamic Light Scattering (MADLS®) improves the resolution of DLS and provides angular independent size results.
  • Simple, material independent measurement of per peak particle concentration.
  • Mean size only requires knowledge of the viscosity of the liquid.
  • Simple or no sample preparation, high concentration, turbid samples can be measured directly using NIBS.
  • Size measurement of sizes from <1nm to >10um
  • Size measurement of molecules from MW < 1000Da.
  • Low volume requirement (as little as 3µL).
  • At-line process systems available for control of nanoparticle manufacture.
  • Compliance with regulatory standards ISO 13321, ISO 22412, 21 CFR Part 11. 
Zetasizer Advance Range

Zetasizer Advance Range

Light Scattering for every application

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Zetasizer AT

Zetasizer AT

On-line particle size analyzer for nano-scale processes

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Technology
Dynamic Light Scattering
Electrophoretic Light Scattering
Static Light Scattering
Measurement type
Particle size
Zeta potential
Molecular weight
Particle size range 0.3nm - 15µm 0.3nm - 10µm