Date recorded: August 15 2019

Duration: 01 hours 05 minutes 54 seconds

Exploring the effect of increasing energy on a particulate system is the general approach to method development in laser diffraction. In this manner agglomerates can be distinguished from primary particles. Energy is applied by altering the differential pressure (P) in a dry measurement in the pressure-size titration approach and in the wet systems by application of ultrasound energy in the before, during, and after sonication (BDAS) approach. This seminar will illustrate the methodologies by means of appropriate examples and reference to ISO 13320: 2009

Table of contents
1. PST and BDAS - an acronym approach to laser diffraction method development
01:55
2. Abstract
00:34
3. Obligatory Opening Quotation (O2Q)
01:24
4. Shameless plug
00:17
5. …as well as Malvern application notes
00:27
6. Developing an SOP (Standard Operating Procedure)
00:57
7. The infamous 4Q’s
02:31
8. How do we know whether there are agglomerates in the system?
00:54
9. Harold Heywood
00:28
10. Design of Experiment
00:51
11. Specification
01:07
12. Why?
00:35
13. Why?
00:36
14. Why?
00:51
15. The 3 R’s and 3 M’s of SOP’s
01:07
16. 3R’s & 3M’s in particle sizing
00:27
17. The golfing analogy
00:25
18. Measures/markers of precision
01:00
19. 3 R’s sorted out in method development
02:04
20. General rules – “large” sizes
00:53
21. General rules – “small” sizes
00:39
22. Dispersion
00:57
23. SOP development - general
01:00
24. Dry and wet
01:53
25. Dry and wet
01:12
26. Dry dispersion - Basics
01:22
27. Venturi type
00:18
28. Method development - dry
00:58
29. Method development - dry
01:22
30. ISO13320: 2009 Section 6.2.3.2 Dispersion in gas
00:43
31. Dry - theoretical and practical plots
00:32
32. Dry - theoretical and practical plots
00:27
33. Dry - example
01:03
34. Dry - example
00:36
35. Dry analysis
00:52
36. Dry – example of attrition
01:02
37. How to look for segregation in a powder
00:16
38. Obscuration control
01:18
39. Obscuration control
01:00
40. Controlling the feed rate (mass flow)
00:50
41. Issues to consider with a dry SOP
01:00
42. Is the dispersion correct?
00:35
43. Stages in making a stable dispersion
00:43
44. Method development - wet
01:29
45. Wet - theoretical and practical plots
00:58
46. Wetting
01:28
47. Wetting
00:33
48. Wetting
00:26
49. Dispersants for Nanometer Size Particles
00:27
50. Stabilization
01:29
51. Ceria - CeO2
01:04
52. Titanium dioxide
00:37
53. Indications that there is a stability issue
00:31
54. Stability studies with Zetasizer plus titrator
01:36
55. Method development - wet
00:23
56. Wet – dry comparison
00:19
57. Wet – dry comparison
00:15
58. Powder Coating - Size/Pressure
00:46
59. Comparison - wet/dry
00:21
60. Comparison between wet and dry
00:11
61. In MS2000 & MS3000 can do this directly
00:14
62. Sample Name – use for any change
00:12
63. Check on method (development)
00:17
64. Points to note
00:21
65. So what D pressure to measure at?
00:30
66. Overlap at what pressure?
00:17
67. Try another material
00:11
68. Toner PST
00:10
69. Wet - dry comparison
00:33
70. General indicators in the PST & BDAS plots
00:21
71. Method development: microsilica
00:22
72. Microsilica
00:16
73. ISO13320: 2009
00:30
74. ISO13320: 2009
00:17
75. Setting up the SOP
00:21
76. What do I need to think about and define before I even attempt a particle size measurement?
00:11
77. Thank you for viewing and listening
00:13
78. Question & Answers
06:33
79. Thank you for your interest
01:11