The complexities of particle sizing are often understated and overlooked, with even regulatory guidelines reducing particle size distribution to a single set of figures with little context. These complexities arise from the different physical attributes particles develop during crystallization and need to be addressed to fully understand the both the crystallization step itself and further downstream processes. To date, it has become commonplace to adopt a “one-size fits all” approach leading to information captured from particle sizing to be limited and at times erroneous.
This webinar shows how coupling the use of a Mastersizer 3000 with orthogonal methods (such as SEM and optical microscopy) enables the avoidance of many common pitfalls in particle sizing. Particle sizing methods should be tailored to produce the most accurate results, and resulting data should be analyzed and scrutinized to ensure the resulting particle size distribution corresponds to the particles being measured.
The APC particle sizing workflow described in this webinar showcases a systematic approach in delivering accurate, reproducible, and representative particle sizing in four phases using Mastersizer 3000 wet methods for particles ranging between 0.01 µm – 3500 µm.
- Phase1: Solid State characterization to identify the compound and polymorph being measured.
- Phase 2: Identifying suitable dispersants, and pairing surfactants if/when needed
- Phase 3: Optimizing parameters of the Mastersizer 3000 to obtain best measurements (obscuration range, refractive index, agitation rate…)
- Phase 4: Correct reporting of particle size distribution.
This method has been successfully implemented in several method development studies in improving sizing methods provided by clients.
This presentation highlights best practice for particle sizing when using a Malvern Mastersizer. It also discusses how to avoid pitfalls and spot ‘red flags’ of sizing methods and explores better methods for reporting particle size distribution.