| 00:00:00 | "Optical properties of organic compounds" |
| 00:00:44 | "Optical properties of organic compounds" |
| 00:01:31 | Abstract |
| 00:02:02 | Determination of real part of refractive index |
| 00:04:15 | General |
| 00:05:56 | We must get the real part right… |
| 00:06:25 | Imaginary part robustness - 3 S’s |
| 00:06:50 | Determination of imaginary part of refractive indexAlways assumes that real part is known |
| 00:08:28 | RI – Becke Lines/Schroeder van der Kolk |
| 00:09:44 | Abbe refractometer |
| 00:10:07 | Prism & ScaleRI = 1.70 top limit |
| 00:10:57 | Saveyn method |
| 00:11:51 | Saveyn et alPartec 2001 |
| 00:12:05 | Saveyn – particle size distribution - robustness |
| 00:12:52 | Reject ridiculous solutions |
| 00:13:15 | Saveyn gives… (2 methods) |
| 00:14:00 | Literature: http://www.guidechem.com/dictionary/137-26-8.html |
| 00:14:35 | ChemSketch |
| 00:15:22 | Quantitative Structure-Activity Relationships |
| 00:16:25 | The Parachor |
| 00:17:15 | Density |
| 00:17:52 | http://webmineral.com/help/CellDimensions.shtml |
| 00:18:50 | RI and density |
| 00:19:08 | RI - Density (Gladstone-Dale et al) – ParticlesCIC, Leeds, UKMeasured density 2.674 g/cm3; Therefore: RI = 1.544Formula from plot is approx. RI = 0.195 + 1.03 (theory 1.0) |
| 00:20:12 | How could you calculate the RI of a G6 dendrimer? |
| 00:20:55 | G6 Dendrimer Zetasizer Nano |
| 00:21:20 | G6 dendrimer – RI calculationBased on CMR3 values for atomic refractivities |
| 00:22:09 | Robustness – imaginary part of RI |
| 00:22:41 | Conclusions - Rawle paper at WCPT7 Beijing |
| 00:23:45 | Conclusions - Rawle paper at WCPT7 Beijing |
| 00:25:01 | Conclusions - Rawle paper at WCPT7 Beijing |
| 00:26:07 | Another material - optical microscope ($800…) |
| 00:26:54 | Robustness – imaginary part of RI |
| 00:28:26 | Volume concentration (ISO 13320:2009) |
| 00:29:39 | Reject poor choices |
| 00:30:25 | New Optical Property Optimizer for Mastersizer 3000 |
| 00:30:25 | The Optimizer – 1.544/0.001 |
| 00:31:22 | Conversion to number – in line with imaging? |
| 00:31:58 | Another material - optical microscope ($800…) |
| 00:32:27 | Try again… (0.1) |
| 00:32:48 | And again… (0.01) – this agrees with the volume concentration experiment – shape slightly different to MS2000 result: multiple scattering? |
| 00:33:09 | 3.0 gives better fit and residual |
| 00:33:42 | 0.0003? Doesn’t fit with volume concentration.. |
| 00:34:04 | So what to do? |
| 00:34:35 | Take care with the fit and residual |
| 00:36:35 | Summary |
| 00:37:11 | Are you a winner or a loser? |
| 00:37:45 | Webinar references |
| 00:38:10 | Contact Information |
Determination of the optical properties of organic compounds is important when carrying out laser diffraction particle size measurements. However, many users struggle to obtain realistic values. In this presentation, we present methods for measuring and calculating these important parameters, enabling good laser diffraction particle size measurements to be carried out. In addition, we introduce a new tool available in the Mastersizer 3000 software which aids users in optimising optical property selections.