Fragment Screening of GPCRs Using GCI

Solutions for Unstable Proteins

Recently, Evotec has utilized Grating Coupled Interferometry (GCI) technology for fragment screening against G protein-coupled receptors (GPCRs). Dr. Edoardo Fabini, a chief researcher at Evotec, commented as follows.

“An important aspect of GPCRs is their low surface activity. They become very unstable when extracted from the natural membrane environment. Therefore, using high-speed and high-sensitivity technologies like GCI opens up new possibilities to confidently quantify weak binding events with low signals.”

At a recent webinar hosted by Malvern Panalytical, Dr. Fabini introduced the challenges associated with GPCR research and the solutions offered by the WAVEsystem, which is designed based on our proprietary GCI technology, to participants.

More details on the fragment screening case with GCI by Evotec can be downloaded below.

Target Industry: Biopharmaceuticals, Pharmaceuticals, Small Molecule Drug Discovery

Challenge: Research on Binding Affinity and Interaction Kinetics of Membrane Proteins with Stability Issues

Equipment Used

Related Content

Recorded Webinar: “Fragment screening of GPCRs using Grating Coupled Interferometry (GCI) technology”

Technical Article: “How to utilize Grating Coupled Interferometry (GCI) for complex membrane proteins”

Technical Note: “Quick characterization of binding onto unpurified GPCRs”